BACKGROUND The St John's Wort (Hypericum perforatum; Clusiaceae) has been used in traditional and modern medicine for a long time due to its high content of biologically active phenolics. The purpose of this work was to develop a method for their fractionation and identification, and to determine the most active antioxidant compounds in plant extract. RESULTS An LC-MS method which enables fas...

A major gene termed Hyp-1 encoding for hypericin (HyH) biosynthesis was cloned and characterized from Hypericum perforatum (St. John's wort) cell cultures. H. perforatum leaves are widely used as an herbal remedy in the treatment of mild to moderate depression. Hypericin, a photosensitive and red-colored naphthodianthrone, has been reported as the bioactive compound responsible for reversing th...

The value of an extract of Hypericum perforatum (St John's wort) for children with mild to moderate depressive symptoms was investigated for the first time in a multi-centre post-marketing surveillance study. One hundred and one children under 12 years were treated for a minimum of 4 weeks with an extension to 6 weeks with parental consent and medical practitioner recommendation. the dosage use...

2 Using Enantiomerically Resolved Cationic 4‐Amino-1,83 naphthalimide-Based Tröger’s Bases 4 Swagata Banerjee,† Sandra A. Bright,‡ Jayden A. Smith,† Jeremy Burgeat,† Miguel Martinez-Calvo,† 5 D. Clive Williams,‡ John M. Kelly,*,† and Thorfinnur Gunnlaugsson*,† 6 †School of Chemistry and Trinity Biomedical Sciences Institute, University of Dublin, Trinity College Dublin, Dublin 2, Ireland 7 ‡Sch...

John Tyndall, Irish-born natural philosopher, completed his PhD at the University of Marburg in 1850 while starting his first substantial period of research into the phenomenon of diamagnetism. This paper provides a detailed analysis and evaluation of his contribution to the understanding of magnetism and of the impact of this work on establishing his own career and reputation; it was instrumen...

An overview is given of the formulation of low-energy string cosmologies together with examples of particular solutions, successes and problems of the theory.

New industrial brewing yeast strains, free of vector sequences and drug-resistance genes, were constructed by disrupting alpha-acetohydroxyacid synthase (AHAS) gene (ILV2) and introducing Lipomyces starkeyi dextranase (DEX) gene (LSD1) as a selective marker. The resulting recombinant strains can survive on YNB minimal medium plate with dextran T-70 as sole carbon source and showed lower AHAS ac...

Running head: 1 Transcriptome coverage and microarray sensitivity 2 3 4 Title: 5 A rapid method for computationally inferring 6 transcriptome coverage and microarray sensitivity 7 8 9 Authors: 10 A. Reverter, S. M. McWilliam, W. Barris and B. P. Dalrymple 11 12 Bioinformatics Group, CSIRO Livestock Industries, 13 Queensland Bioscience Precinct, 306 Carmody Rd., St. Lucia, QLD 4067, Australia 14...

Roland Schermaul,∗ Richard C. M. Learner,∗,1 David A. Newnham,† John Ballard,† Nikolai F. Zobov,‡ Djedjiga Belmiloud,† and Jonathan Tennyson‡ ∗Laser Optics and Spectroscopy, Blackett Laboratory, Imperial College of Science, Technology and Medicine, Prince Consort Road, London SW7 2BW, United Kingdom; †Atmospheric Science Division, Space Science and Technology Department, Rutherford Appleton Lab...