PURPOSE To investigate the correlation among p300, CBP and MLL expression and the clinicopathological characteristics in resected SCLC patients. METHODS Two hundred and twenty-two resected SCLC patients were included in this study. We evaluated p300, CBP and MLL expression by immunohistochemistry. RESULTS Patients with high p300 expression had shorter OS and DFS than those with low p300 exp...

BACKGROUND The acceleration forces infringing the cervical spine in whiplash injury are frequently associated with multiple cerebral symptoms. The purpose of this study was to determine whether there is a correlation between cerebral perfusion findings, P300 recording (an electrophysiologic marker of cognitive ability), and neuropsychological tests in patients with whiplash injury. METHODS Tw...

Muscle proteolysis during sepsis and other catabolic conditions is, at least in part, regulated by glucocorticoids. Dexamethasone-treated myotubes are a commonly used in vitro model of muscle wasting. We reported recently that treatment of cultured L6 myotubes with dexamethasone resulted in increased gene and protein expression of the nuclear cofactor p300 but it is not known whether glucocorti...

Cyclic adenosine monophosphate response element binding (CREB)-binding protein (CBP) and p300 are multidomain transcriptional coactivators that help assemble large regulatory complexes at sites of active transcription. Nullizygosity of CBP or p300 results in pervasive defects in hematopoiesis. To systematically assess the structural domains of p300 required for normal hematopoiesis, we used rec...

AIM In the present study, the P300 component of the emotion-loaded visual event-related potential in response to photographs of babies crying or smiling was measured to evaluate cognitive function in elderly subjects, including those with dementia. METHODS The subjects were 48 elderly people who consulted a memory disorder clinic. The visual event-related potential was measured using oddball ...

NF-κB plays a vital role in cellular immune and inflammatory response, survival, and proliferation by regulating the transcription of various genes involved in these processes. To activate transcription, RelA (a prominent NF-κB family member) interacts with transcriptional co-activators like CREB-binding protein (CBP) and its paralog p300 in addition to its cognate κB sites on the promoter/enha...

Evaluation of cognitive functions in Parkinson’s patients without dementia with auditory event related potential (P300) Objective: Idiopathic Parkinson’s disease is a clinical situation characterized by akinesia, rigidity, and tremor, and results from the degeneration of the dopaminergic nervous system. As the disease progresses over time, depression, cognitive dysfunction and alterations in co...

The purpose of this study was to determine whether certain previously reported relationships between event-related potentials and measures of signal detection performance occur in vigilance as well as psychophysical settings. In the course of the study, evidence was found which challenges previously proposed psychological correlates of "P300". EEG was recorded while 15 subjects carried out a 40...

Using a stepwise discriminant analysis, we demonstrate that the amplitude of P300 is a graded function of the complexity of information processing required of a S following a stimulus. This relationship between cognitive complexity and P300 is apparent only when the S is not pressed to generate fast and accurate discriminant responses to the stimuli. Under a reaction-time regime, a large P300 i...

The P300 component of Event Related Brain Potentials (ERP) is commonly used in Brain Computer Interfaces (BCI) to translate the intentions of an individual into commands for external devices. The P300 response, however, resides in a signal environment of high background noise. Consequently, the main problem in developing a P300-based BCI lies in identifying the P300 response in the presence of ...