Dichloroacetate (DCA) is a pyruvate dehydrogenase activator that increases cardiac efficiency during reperfusion of ischemic hearts. We determined whether DCA increases efficiency of mitochondrial ATP production by measuring proton leak in mitochondria from isolated working rat hearts subjected to 30 min of ischemia and 60 min of reperfusion. In untreated hearts, cardiac work and efficiency dec...

With the evolution of analog mobile wireless communications systems into digital secondand third-generation systems, there is growing interest in finding more efficient ways of managing the available resources, in particular radio spectrum and power. In the context of time division multiple access (TDMA) systems, this interest has led to the development of a variety of dynamic channel assignmen...

2 3 4 5 6 7 Julie Greensmith · Jan Feyereisl · Uwe Aickelin 8 9 The DCA: SOMe Comparison 10 11 A comparative study between two biologically-inspired algorithms 12 13 14 15 16 17 Received: date / Accepted: date 18 19 20 Abstract The Dendritic Cell Algorithm (DCA) is an immune-inspired algorithm, developed for the 21 purpose of anomaly detection. The algorithm performs multi-sensor data fusion an...

The aim of this study was to evaluate the metabolic profile of human prostate cancer cells that have different metastatic potential and to determine their response to dichloroacetate (DCA) using NMR technology. Two isogenic human prostate cancer cell lines, differing in their metastatic potential [LNCaP (poorly metastatic) and LNCaP-LN3 (highly metastatic)], were studied. Metabolite ratios from...

The special importance of Difference of Convex DC functions programming has been recognized in recent studies on nonconvex optimization problems. In this work, a class of DC programming derived from the portfolio selection problems is studied. The most popular method applied to solve the problem is the Branch-and-Bound B&B algorithm. However, “the curse of dimensionality” will affect the perfor...

A cluster of 18 open reading frames (ORFs), 15 of which are homologous to genes involved in division and cell wall synthesis, has been identified in Neisseria gonorrhoeae and Neisseria meningitidis. The three additional ORFs, internal to the dcw cluster, are not homologous to dcw-related genes present in other bacterial species. Analysis of the N. meningitidis strain MC58 genome for foreign DNA...

Targeting reprogrammed energy metabolism such as aerobic glycolysis is a potential strategy for cancer treatment. However, tumors exhibiting low-rate glycolysis or metabolic heterogeneity might be resistant to such treatment. We hypothesized that a therapeutic modality that drove cancer cells to high-rate glycolysis might sensitize cancer cells to interference directed against metabolic flux. I...

A new fault attack, double counting attack (DCA), on the precomputation of 2t-ary modular exponentiation for a classical RSA digital signature (i.e., RSA without the Chinese remainder theorem) is proposed. The 2t-ary method is the most popular and widely used algorithm to speed up the RSA signature process. Developers can realize the fastest signature process by choosing optimum t. For example,...

The anti-leukemic activity of the mitochondria-targeting small molecule sodium dichloroacetate (DCA), used alone and in association with the small molecule inhibitor of the p53/MDM2 interaction Nutlin-3, was analyzed in primary B-chronic lymphocytic leukemia (B-CLL) samples (n=22), normal peripheral blood cells (n=10) and in p53wild-type EHEB, JVM-2, JVM-3 B lymphoblastoid cell lines. DCA exhib...

BACKGROUND/AIMS Acute activation of sympathetic activation during hemodialysis is essential to maintain blood pressure (BP), albeit long-term overactivity contributes to higher mortality. Low heart rate variability (HRV), a measure of autonomic nervous system activity, and abnormal ankle-brachial index (ABI) are associated with higher mortality in patients on hemodialysis. In this study, we ass...