As part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Blum et al., 2015), that described how we intended to replicate selected experiments from the paper 'Transcriptional amplification in tumor cells with elevated c-Myc' (Lin et al., 2012). Here we report the results. We found overexpression of c-Myc increased total levels of RNA in P493-6 Burkitt's lymphoma ...

2-Ammoniobutenynyl Ru-complexes trans-[Cl(dppm)2Ru-CtC-C(NR2R′)dCH2]PF6 (3ag) have been prepared in a one-pot procedure from cis-[RuCl2(dppm)2], excess butadiyne, and various tertairy amines, whereas 4-(dimethylamino)pyridine binds to the unsaturated carbon ligand via the pyridine nitrogen to give 3h. These results may be rationalized by envoking the butatrienylidene complex trans-[Cl(dppm)2Rud...

A new, unstable, organ-specific Adh1 mutant was isolated from a Robertson's mutator line by germinating kernels under partial anaerobic conditions. Families of kernels which showed segregation of a conditional anaerobic lethal phenotype were identified. One mutant, Adh1-3F1124, was shown to express approximately 6% normal levels of ADH1 in seed and anaerobically treated seedlings but expresses ...

Byzantine fault-tolerant storage systems can provide high availability in hazardous environments, but the redundant servers they require increase software development and hardware costs. In order to minimize the number of servers required to implement fault-tolerant storage services, we develop a new algorithm that uses a “Listeners” pattern of network communication to detect and resolve orderi...

Bispectral and trispectral analyses are used to detect secondary and tertiary wave components resulting from nonlinear interactions among largeamplitude ocean surface gravity waves in 8and 13-m water depths. Bispectra of bottom-pressure measurements indicate forced secondary waves at frequencies 2fp about twice the primary power spectral peak frequency fp. However, the interpretation of the bis...

Drugs such as necopidem, saripidem, alpidem, zolpidem, and olprinone contain nitrogen-containing bicyclic, condensed-imidazo[1,2-α]pyridines as bioactive scaffolds. In this work, we report a high-yield one pot synthesis of 1-(2-methyl-8-aryl-substitued-imidazo[1,2-α]pyridin-3-yl)ethan-1-onefor the first-time. Subsequently, we performed in silico mode-of-action analysis and predicted that the sy...