The Polycomb group (PcG) genes are required for maintenance of homeotic gene repression during development. Mutations in these genes can be suppressed by mutations in genes of the SWI/SNF family. We have purified a complex, termed PRC1 (Polycomb repressive complex 1), that contains the products of the PcG genes Polycomb, Posterior sex combs, polyhomeotic, Sex combs on midleg, and several other ...

Introduction: Susceptibility weighted imaging (SWI) has been used for some time as a means to enhance venous vessels using high pass filtered phase images [1,2]. However, efficacy of SWI processing relies especially on an asymmetric voxel aspect ratio [3] and to a slight extent on the relative orientation of the head and the main magnetic field. Therefore, when SWI is collected as high resoluti...

SWI/SNF chromatin remodeling complexes are pleomorphic multisubunit cellular machines that utilize the energy of ATP hydrolysis to modulate chromatin structure. The complexes interact with transcription factors at promoters and enhancers to modulate gene expression and contribute to lineage specification, differentiation, and development. Initial clues to a role in tumor suppression for SWI/SNF...

BACKGROUND Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disorder, characterised by widespread white matter damage. There is growing evidence that disturbances in iron metabolism contribute to white matter alterations. MATERIALS & METHODS We analysed the data of susceptibility-weighted imaging (SWI) of white matter in a cohort of 27 patients with ALS and 30 hea...

UNLABELLED SWI/SNF is a major regulator of gene expression. Its role is to facilitate the shifting and exposure of DNA segments within the promoter and other key domains to transcription factors and other essential cellular proteins. This complex interacts with a wide range of proteins and does not function within a single, specific pathway; thus, it is involved in a multitude of cellular proce...

Introduction: Susceptibility-weighted imaging (SWI) is a newly developed approach to enhance contrast between tissues with different magnetic susceptibilities [1]. SWI takes advantage of the high sensitivity of NMR phase images to tissue susceptibility differences, and enhances image contrast in magnitude images using NMR phase images as masks. In addition to its initial application for imaging...

The SWI/SNF chromatin-remodeling family contains various protein complexes, which regulate gene expression during cellular development and influence DNA damage response in anATPand complex-dependent manner, of which details remain elusive. Recent human genome sequencing of various cancer cells revealed frequentmutations in SWI/SNF factors, especially ARID1A, a variant subunit in the BRG1-associ...

OBJECTIVES This study aimed to evaluate the detectability of stem cells labeled with very small iron oxide particles (VSOP) at 3T with susceptibility weighted (SWI) and T2* weighted imaging as a methodological basis for subsequent examinations in a large animal stroke model (sheep). MATERIALS AND METHODS We examined ovine mesenchymal stem cells labeled with VSOP in agarose layer phantoms. The...

Susceptibility-weighted imaging (SWI) detects hypointensities due to iron deposition and deoxyhemoglobin. Previously it was shown that SWI detects hypointensities in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS), most of which are due to intravascular deoxyhemoglobin, with a small proportion being due to iron deposition in the central nervous system parenc...

Chromatin remodeling has been newly established as an important cancer genome characterization and recent exome and whole-genome sequencing studies of hepatocellular carcinoma (HCC) showed that recurrent inactivating mutations in SWI/SNF subunits involved in the molecular basis of hepatocarcinogenesis. To test the hypothesis that genetic variants in the key subunits of SWI/SNF complexes may con...