نتایج جستجو برای: شاخص sledai
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BACKGROUND To determine the prevalence of cryoglobulins in Iranian patients with systemic lupus erythematosus (SLE) and evaluate the correlation of cryoglobulins with disease activity in these patients. MATERIALS AND METHODS In a cross-sectional study, we investigated 80 consecutive women who fulfilled the 1982 revised criteria of the American College of Rheumatology for the classification of...
BACKGROUND The incidence and prevalence of CNS involvement in SLE remains unclear owing to conflicting results in the published studies. The aim of the study was to evaluate the incidence and prevalence of major definite CNS events in SLE patients. METHODS 370 SLE patients with no previous history of CNS involvement were prospectively evaluated in a tertiary hospital referral center for 3 yea...
In a time of increasing economic constraints, it is crucial that health systems optimize their resource use to ensure that they generate the maximum possible health gain. Therefore, it is necessary for health interventions to be evaluated and compared across therapeutic boundaries. Undertaking such an evaluation a generic utility-based measure is required. But it remains uncertain whether the u...
OBJECTIVE The objective of this article is to evaluate the safety and clinical outcome of rituximab treatment in systemic lupus erythematosus (SLE) patients refractory to standard of care therapy in a real-life setting in Germany. METHODS The GRAID registry included patients with different autoimmune diseases who were given off-label treatment with rituximab. Data on safety and clinical respo...
To determine the expression of mTOR, Becline-1, LC3 and p62 in the peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematosus (SLE) and assess their relationship with disease activity and immunologic features. The expression of mTOR, Becline-1, LC3 and p62 was detected by RT-PCR in 81 SLE subjects and 86 age- and sex-matched healthy controls. Data regarding demographics and clin...
Case presentation: L.S.O., female, 15 years old, hospitalized for peaks of fever, anemia, positive direct coombs, hypocomplementemia and proteinuria >0.5 g/24h. Pulse therapy with methylprednisolone was prescribed the hypothesis systemic lupus erythematosus (SLE). Evolved severe headache convulsive crises presenting cortical, subcortical, posterior bilateral hypodensity on cranial tomography. P...
Abstract Background and Aims Lupus nephritis (LN) is a severe renal manifestation of systemic lupus erythematosus (SLE) that negatively impacts morbidity mortality; however, real-world data for LN scarce. This study describes: the proportion patients with SLE managed by rheumatologists (rheum-managed) nephrologists (neph-managed) class III–V; Safety Estrogens in Erythematosus National Assessmen...
زمینه و هدف: تحقیقات اخیر نشان داده اند که پرولاکتین می تواند نقشی در پاتوژنز بیماری لوپوس ( systematic lupus erythematosus= sle ) داشته باشد. این هورمون پپتیدی با تحریک سیستم ایمنی می تواند باعث تشدید فعالیت بیماری لوپوس گردد. هدف از این تحقیق نشان دادن رابطه سطح پرولاکتین سرم و میزان فعالیت بیماری لوپوس است. روش کار: این مطالعه توصیفی ـ تحلیلی بر روی 35 بیمار مبتلا به لوپوس که به صورت تصادفی ...
background: recent accumulated evidence suggests that prolactin (prl) is an important immunomodulator and plays an important role in the pathogenesis of systemic lupus erythematosus (sle). the current study aimed to compare hyperprolactinemia frequency and evaluate its possible association with lupus activity in sle patients in zahedan. methods: in a case-control study we determined serum prola...
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