OBJECTIVES Inflammation-based prognostic markers (neutrophil-lymphocyte ratio (NLR), prognostic nutritional index (PNI), red cell distribution width (RDW) and lymphocyte-monocyte ratio (LMR)) are associated with overall survival in some diseases. This study assessed their prognostic value in mortality and severity in acute pancreatitis (AP). DESIGN A retrospective cohort study. SETTING Pati...

OBJECTIVE To more precisely define the risk of non-organ-confined (non-OC) prostate cancer among men with perineural invasion (PNI) identified on prostate biopsy. MATERIALS AND METHODS The Johns Hopkins radical prostatectomy database was queried for men with PNI reported on prostate biopsy. Patients with and without non-OC disease were compared for differences in preoperative clinical and pat...

A inovação frugal tem ganhado espaço no círculo acadêmico e empresarial nos últimos anos. Nesse contexto, o objetivo do estudo é analisar a predisposição das empresas vencedoras Prêmio Nacional de Inovação (PNI) para frugal. Para tanto, utilizou-se dados secundários dos relatórios três últimas edições PNI da análise qualitativa destes dados. Ao total foram analisadas 52 empresas. Os resultados ...

Previous studies have shown that the C-reactive protein/albumin ratio (CAR) is a prognostic indicator in multiple types of carcinomas. This study is the first to evaluate the prognostic significance of CAR in stage IB-IIA cervical cancer patients treated with radical surgery, as well as that of several other inflammation-based factors, including the neutrophil-to-lymphocyte ratio (NLR), platele...

BACKGROUND AND AIMS Nestin is considered to be a marker of stem/progenitor cells in different tissues. Nestin expression was also described in various tumors. In pancreatic ductal adenocarcinoma (PDAC), its role in cancer cell migration, invasion, and metastases has been suggested. The study aimed at examining the expression of nestin in PDAC, and to evaluate its clinicopathological correlation...

BACKGROUND/AIMS Pretreatment nutritional status is an important prognostic factor in patients treated with conventional cytotoxic chemotherapy. In the era of target therapies, its value is overlooked and has not been investigated. The aim of our study is to evaluate the value of nutritional status in targeted therapy. METHODS A total of 2012 patients with non-small cell lung cancer (NSCLC) we...

Peripheral nerve injury (PNI) usually leads to progressive muscle atrophy and poor functional recovery. Previous studies have demonstrated that non-coding ribonucleic acid (ncRNA) is a key regulator of muscle atrophy and beneficial for the treatment of PNI. We aimed to analyze the whole transcriptome involved in denervated muscle atrophy after PNI. Animal models of sciatic nerve injury were ass...

Drought is an unpredictable hydrological phenomenon, and climate change has made it difficult to predict analyze droughts. Nyala city airport metrological station rainfall records from 1943 2017 (75 years) were investigated. Four statistical drought indices used; the standardized precipitation index (SPI), anomaly (RAI), decile percent (RDI), normal (PNI). The study analyzes, assesses, compares...

Aim: Systemic immune-inflammation indexes have been reported to be associated with clinical outcomes in several malignancies. Herein, we aimed evaluate the potential relationship between prognostic nutritional index (PNI), systemic (SII), neutrophil- to- lymphocyte ratio (NLR), monocyte- (MLR), platelet-to-lymphocyte (PLR) and treatment response patients esophageal cancer who underwent neoadjuv...

The presence of an inflammatory response is crucial in the development of cancer-associated malnutrition, resulting in poor performance status and increased mortality in patients with cancer. On the basis of the relationship between inflammation and cancer progression, several inflammation-based scores have been proposed as prognostic. The main scores that have been associated with cancer-speci...