Our approach to model and represent multidimensional data for explorative data analysis [16] is guided by our experience in the context of epidemiological cancer research. The project CARLOS (Cancer Registry Lower-Saxony) developed the Epidemiological and Statistical Data Exploration System (CARESS) to support multidimensional analysis of health data. The system is based on an architecture that...

Targeted therapeutics such as monoclonal antibodies (mAbs) have proven successful as cancer drugs. To profile products that could be marketed in the future, we examined the current commercial clinical pipeline of mAb candidates for cancer. Our analysis revealed trends toward development of a variety of noncanonical mAbs, including antibody-drug conjugates (ADCs), bispecific antibodies, engineer...

This article examines the role of mode of acquisition (MoA) of word meanings in reading comprehension: children acquire word meanings using perceptual information (e.g., hearing, seeing, or smelling the referent) and/or linguistic information (e.g., verbal explanations). A total of 72 deaf and 99 hearing children between 7 and 15 years of age performed a self-paced reading task. Comprehension s...

This research investigates similarities between cancer-related drugs with respect to their mechanisms of action (MOA) guided by information extracted from two resources: scientific literature and ontologies. To find similarity between drug pairs, the Chemical Entities of Biological Interest (ChEBI) ontology and Gene Ontology (GO) were leveraged to compute drug and drug target features, respecti...

Insect nicotinic acetylcholine receptors (nAChRs) are among the most prominent and most economically important insecticide targets. Thus, an understanding of the modes of binding of respective agonists is important for the design of specific compounds with favorable vertebrate profiles. In the case of nAChRs, the lack of available high-resolution X-ray structures leaves theoretical consideratio...

This article considers the performance of the MOA* multiobjective search algorithm with heuristic information. It is shown that in certain cases blind search can be more efficient than perfectly informed search, in terms of both node and label expansions. A class of simple graph search problems is defined for which the number of nodes grows linearly with problem size and the number of nondomina...

The application of foraging theory to understanding carcass exploitation is a relatively recent development. The methodology developed by archaeological and ethnoarchaeological research on butchery/transport studies has been integrated into a behavioral ecological framework to create models that can be used to understand archaeological carcass exploitation. In this paper, I use such a model to ...

Five subjects mimicked the sensation caused by their tinnitus with a complex sound pattern consisting of the sum of sine waves. The imitation tinnitus was generally broadband, spanning an average of 2.94 kHz. Measures of the pitch of the tinnitus were made using both a forced-choice double-staircase (FCDS) task and a method of adjustment (MOA) task. Even tinnitus portrayed as broadband was matc...

In the gift exchange game there are n players and n wrapped gifts. When a player’s number is called, that person can either choose one of the remaining wrapped gifts, or can “steal” a gift from someone who has already unwrapped it, subject to the restriction that no gift can be stolen more than a total of σ times. The problem is to determine the number of ways that the game can be played out, f...