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Practicalities of using an adaptive design for decision making within the optima trial: optimal personalized treatment of early breast cancer using multi-parameter tests Janet Dunn, Andrea Marshall, Amy Campbell, David Cameron, Helena Earl, Iain Macpherson, Christopher Poole, Daniel Rea, Adele Francis, Victoria Harmer, Adrienne Morgan, Nigel Stallard, Andreas Makris, Luke Hughes-Davies, Robert ...
The association ofHelicobacter pyloriwith peptic ulcer disease and gastric cancer was first proposed by Warren and Marshall in 1983 (Warren and Marshall, 1983). In February 1994, the National Institutes of Health Consensus Development Conference concluded thatH. pylori infection is themajor cause of peptic ulcer disease, and all patients with confirmed peptic ulcer disease associatedwithH. pylo...
BACKGROUND Chronic instability of the acromiocavicular joint is relatively common and normally occurs following a fall onto the point of the shoulder. Reconstruction of the joint [Weaver-Dunn procedure] using the coracoacromial ligament is often required in service personnel, and a number of methods to augment this repair have been used. Many of these operative methods require a second operatio...
One of the aims of cognitive (neuro)psychology is to characterize the nature of, and the relationships between, mental processes underlying human behavior (c.f. Dunn & Kirsner, this issue). In this context, the double dissociation (DD) paradigm has played an important albeit debated role. In our efforts to come up with a clear and positive contribution to this discussion, which sometimes appear...
formulations of genetics leave us less and less tangible knowledge of how the genes work. We can only hope that genetics has asked the right questions, which are now ready for the frontal attacks of biochemistry. 1. Allison, A. C., Science 122, 640. (1955). 2. Beadle, G. W., in “Genetics in the 20th Century” (L. C. Dunn, ed.). The
1 Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, MA, USA 2 Department of Medicine, Harvard Medical School, Boston, MA, USA 3 Harvard Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA 4 T Cell Signalling Laboratory, Department of Pathology, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK *Correspondence: [email protected]...
B. Zielbauer, D. Ursescu, C. Bischoff, D. Zimmer, T. Kühl, V. Bagnoud, D. Javorkova, O. Rosmej, K. Cassou, S. Kazamias, A. Klisnick, D. Ros, K. Janulewicz, P. Nickles, G. Pert, P. Neumayer, J. Dunn Gesellschaft für Schwerionenforschung (GSI), Darmstadt, Germany; Universität Mainz, Mainz, Germany; Max Born Insitut, Berlin, Germany; Université Paris XI, Paris, France; York University, United King...
The metabolism of certain inorganic forms of sulfur by various autotropic bacteria has been studied extensively in the past. However, investigations dealing with the metabolism of sulfur compounds by the heterotropic bacteria have not been numerous. Such work as has been done (reviewed by Meyers and Porter (1)) indicates that these microbial systems may be quite specific in their requirements f...
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