Objetivo: analisar o perfil de morbimortalidade pacientes hospitalizados por COVID-19 e discutir os achados pertinentes na literatura. Método: Trata-se uma revisão integrativa. Foram encontrados 538 estudos, destes, 29 foram incluídos para a revisão. Resultados: com maiores taxas hospitalizações óbitos são do sexo masculino, faixa etária maior que 60 anos idade, portadores doenças crônicas, ten...

با توجه به اثر عوامل تصادفی مانند خرابی ماشین‌ها بر قدرت رقابتی سازمان‌های تولیدی، اهمیت برنامه‌ریزی تولید دوچندان شده است. لذا سیستم‌های تولیدی مستعد شکست برای مقابله این عدم قطعیت، پدید آمده‌اند. جهت حفظ سهم در بازار رقابت و افزایش بهره‌وری، صنعتی اسـتراتژی نگهداری تعمیرات به‌منظور کاهش نرخ قابلیت اطمینان روی آورده‌اند. ظرفیت تولید، فراهم­آوردن انعطاف‌پذیری بیشتر از رضایت‌مندی مشتری نظر کمیّت،...

Background: KRAS is frequently mutated in non-small cell lung cancer (NSCLC) and other tumor types, with G12C mutation representing ∼9% of NSCLC patients. mTOR pathway often activated patients contributes to adaptive resistance inhibitors. A combination inhibitors may mitigate resistance. nab-Sirolimus a novel albumin-bound nanoparticle form inhibitor sirolimus approved for the treatment locall...

“Thermal Referral (TR)” and “Thermal Grill Illusion (TGI)” are known as illusions of thermal sensation, have been well studied. In a previous study, the experiment using two thermal-tactile stimulations to the forearm revealed that those illusions simultaneously occurred. On the other hand, in the experiment result, a few subjects perceived a hot stimulation as a cold sensation or a cold stimul...

This study focused on the substitution effect at position C7 of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines. Compound 9, (E)-3-(7-amino-1-(4-methoxyphenylsulfonyl)indolin-5-yl)-N-hydroxyacrylamide, displayed 4- to 14-fold more potent antiproliferative activity than vorinostat (SAHA, 1). Notably, 9 possessed specific histone deacetylase (HDAC) inhibitory activity toward HDAC1 and HDAC2, but ...