نتایج جستجو برای: سیستم گروه خونی hh
تعداد نتایج: 191651 فیلتر نتایج به سال:
این پژوهش به‌منظور بررسی تأثیر رتینول استات بر عملکرد سامانۀ ایمنی خروسهای گلۀ مادر گوشتی و همچنین مشخص کردن میزان رتینول استات ترانس در جیره برای بیشترین فعالیتهای ایمنی، انجام شد. بدین منظور از 60 قطعه خروس مادر گوشتی راس 308 استفاده شد. طرح آزمایشی در قالب طرح کامل تصادفی با پنج تیمار (0 (R-0)، 6000 (R-6)، 12000 (R-12)، 18000 (R-18)، 24000 (R-24) واحد بین‌المللی رتینول استات افزوده‌شده در ...
The sex determination master switch, Sex-lethal (Sxl), controls sexual development as a splicing and translational regulator. Hedgehog (Hh) is a secreted protein that specifies cell fate during development. We show that Sxl is in a complex that contains all of the known Hh cytoplasmic components, including Cubitus interruptus (Ci) the only known target of Hh signaling. Hh promotes the entry of ...
We present a detailed study of the Herbig-Haro objects HH 80/81, twin working surfaces in the highly collimated outÑow driven by a luminous young star. High angular resolution emission line images obtained with the Hubble Space Telescope are used together with ground-based lowand high-dispersion spectroscopy, and proper motion measurements to provide a comprehensive picture of the structure and...
Hedgehog (Hh) and Wingless (Wg) morphogens specify cell fate in a concentration-dependent manner in the Drosophila wing imaginal disc. Proteoglycans, components of the extracellular matrix, are involved in Hh and Wg stability, spreading, and reception. In this study, we demonstrate that the glycosyl-phosphatidyl-inositol (GPI) anchor of the glypican Dally-like (Dlp) is required for its apical i...
Upregulation of Patched (Ptc), the Drosophila Hedgehog (Hh) receptor in response to Hh signaling limits the range of signaling within a target field by sequestering Hh. In vertebrates, Ptch1 also exhibits ligand-dependent transcriptional activation, but mutants lacking this response show surprisingly normal early development. The identification of Hh-interacting protein 1 (Hhip1), a vertebrate-...
Hedgehog (Hh) proteins play diverse organizing roles in development by regulating gene expression in responding cells. The Gli homolog Cubitus interruptus (Ci) is involved in controlling the transcription of Hh target genes. A repressor form of Ci arises in the absence of Hh signaling by proteolytic cleavage of intact Ci. We show that this cleavage is essential for limb patterning and is regula...
The binding of Hedgehog (Hh) to its receptor Patched causes derepression of Smoothened (Smo), resulting in the activation of the Hh pathway. Here, we show that Smo activation is dependent on the levels of the phospholipid phosphatidylinositol-4 phosphate (PI4P). Loss of STT4 kinase, which is required for the generation of PI4P, exhibits hh loss-of-function phenotypes, whereas loss of Sac1 phosp...
The Hedgehog signalling pathway is crucial for development, adult stem cell maintenance, cell migration and axon guidance in a wide range of organisms. During development, the Hh morphogen directs tissue patterning according to a concentration gradient. Lipid modifications on Hh are needed to achieve graded distribution, leading to debate about how Hh is transported to target cells despite bein...
Members of the Hedgehog (Hh) family encode secreted molecules that act as potent organizers during vertebrate and invertebrate development. Post-translational modification regulates both the range and efficacy of Hh protein. One such modification is the acylation of the N-terminal cysteine of Hh. In a screen for zygotic lethal mutations associated with maternal effects, we have identified rasp,...
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