Addition of benzamide (BZ) at the onset of S phase inhibited expression of the neoplastic phenotype in human foreskin fibroblasts treated in vitro with (+/-)-7 alpha,8 beta-dihydroxy-9 beta,10 beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P diol epoxide) in early S phase. Analysis of the specific B[a]P diol epoxide-DNA adducts revealed that ca. 65% of the total adducts in BZ and non-BZ carc...

A cohort of 123 adult contacts was followed for 18-24 months (86 completed the follow-up) to compare conversion and reversion rates based on two serial measures of QuantiFERON (QFT) and tuberculin skin test (TST) (PPD from TUBERSOL, Aventis Pasteur, Canada) for diagnosing latent tuberculosis (TB) in household contacts of TB patients using conventional (C) and borderline zone (BZ) definitions. Q...

AIM To assess the scalability, reliability and validity of a newly constructed self-report questionnaire on craving for benzodiazepines (BZs), the Benzodiazepine Craving Questionnaire (BCQ). SETTING AND PARTICIPANTS The BCQ was administered once to a sample of 113 long-term and 80 former long-term general practice BZ users participating in a large BZ reduction trial in general practice. MEA...

The evolutions of the geomagnetic Dst and auroral indices AU, AL, AE were examined in relation to interplanetary parameters for thirteen severe storms (Dst change exceeding 250 nT) during 1980-2003. Dst changes occurred every time Bz component of interplanetary magnetic field B turned negative. Among the auroral indices, changes in AU (representing an eastward auroral electrojet) were generally...

Mycobacterium avium subsp. paratuberculosis is the etiologic agent of Johne's disease, a chronic granulomatous enteritis in ruminants. ATP has been reported to induce cell death of macrophages and killing of Mycobacterium species in human and murine macrophages. In this study we investigated the short-term effect of ATP on the viability of M. avium subsp. paratuberculosis-infected bovine mononu...

Imaging the charge distributions and structures of molecules clusters will promote understanding dynamics quantum system. Here, we report a method by using an Ar atom as tip to probe benzene (Bz) cations in gas phase. Remarkably, measured Bz cation (QH =0.204,QC=-0.037)and dication =0.248,QC=0.0853)agree well with calculated Mulliken distributions,and dimer is reconstructed distributions. The t...

Electrophysiological data suggest that an abnormal oscillatory pattern of discharge in cortical and thalamic neurons may be the major mechanism underlying primary generalised epilepsy. No neurochemical or anatomical substrate for this theory has hitherto been demonstrated in humans and the pathophysiology of primary generalised epilepsy remains unknown. By means of PET and the benzodiazepine (B...

Anxiety is a common psychiatric illness often treated by benzodiazepines (BZs). BZs, such as Valium, bind to the a subunit of the pentameric GABAA receptor and increase inhibition in the CNS. There is considerable evidence for abnormal GABAA receptor function in anxiety, and a significant proportion of anxiety patients has a reduced sensitivity to BZs. Here, we show that serotonin1A (5-HT1A) re...

Using a van der Waals density functional vdW-DF Phys. Rev. Lett. 92, 246401 2004 , we perform ab initio calculations for the adsorption energy of benzene Bz on Cu 111 as a function of lateral position and height. We find that the vdW-DF inclusion of nonlocal correlations responsible for dispersive interactions changes the relative stability of eight binding-position options and increases the bi...