Our understanding of the physiology of muscle depends critically on the resolution of the available anatomy. Early insight was provided by light microscopy. However, the first radical new insight was provided by electron microscopy. Ultimately, an understanding in physicochemical terms is only possible if the structures of the components in various physiological states are known at atomic resol...

S100A4, a member of the S100 family of Ca2+-binding proteins, displays elevated expression in malignant human tumors compared with benign tumors, and increased expression correlates strongly with poor patient survival. S100A4 has a direct role in metastatic progression, likely due to the modulation of actomyosin cytoskeletal dynamics, which results in increased cellular motility. We developed a...

REFERENCES 1. DeNavas-Walt C, Proctor BD, Smith JC. Income, Poverty, and Health Insurance Coverage in the United States: 2008. In: U.S. Census Bureau CPR, editor. . Washington, DC: U.S. Government Printing Office; 2009:60-236. 2. Lantz PM, House JS, Lepkowski JM, Williams DR, Mero RP, Chen J. Socioeconomic factors, health behaviors, and mortality: results from a nationally representative prospe...

INTRODUCTION As we know from several studies, the fiber structure and the mechanical properties of a muscle depends on the innervation frequency, innervation time (IT) and the innervation–rest ratio (Monster et al. 1978; Hennig and Lømo 1985; Gundersen and Eken 1992). Recently Hämälainen & Pette (1996) reported that it is possible not only to transform fast contracting MHC II fibers to slow con...

Laser spectroscopy and ion mobility spectrometry are combined to provide structural and photochemical information on photoisomerizing molecules in the gas phase. The strategy exploits the fact that an ion packet propelled through buffer gas by an electric field separates spatially and temporally into its constituent isomers because of small differences in their collision cross sections. Isomers...

The cell wall of M. tuberculosis is central to its success as a pathogen. Mycolic acids are key components of this cell wall. The genes involved in joining the alpha and mero mycolates are located in a cluster, beginning with Rv3799c and extending at least until Rv3804c. The role of each enzyme encoded by these five genes is fairly well understood, except for Rv3802c. Rv3802 is one of seven put...

As disputas envolvendo as políticas sociais durante a pandemia de Covid-19 foram intensas. No âmbito educacional, medidas distanciamento social resultaram no fechamento das escolas e na consequente necessidade adoção emergenciais para enfrentar os desafios educacionais impostos. Este artigo busca contribuir análise dessas políticas, indicando como consequência o risco avanço da privatização edu...

Este trabalho busca compreender a prática do direito defesa no âmbito das audiências de custódia e, desse modo, debater incorporação princípios acusatoriais diante da prisão em flagrante. Para sua elaboração, foram utilizados dados qualitativos e quantitativos, produzidos pela pesquisa monitoramento executada pelo Centro Estudos Criminalidade Segurança Pública (Crisp/ UFMG), parceria com o Inst...