Recent studies have examined the relationship between genetic polymorphisms of the human cytochrome P4501A1 (CYP1A1) gene and lung cancer susceptibility. We have quantified genotypic frequencies and measured gene expression in the CYP1A 1 gene within racially diverse groups in order to determine the relationship between genotype and transcriptional regulation of the CYP1A 1 gene. Lymphocytes we...

Rodent models exhibit only the earliest features of human diabetic nephropathy, which limits our ability to investigate new therapies. Hypertension is a prerequisite for advanced diabetic nephropathy in humans, so its rarity in typical rodent models may partly explain their resistance to nephropathy. Here, we used the Cyp1a1mRen2 rat, in which the murine renin-2 gene is incorporated under the C...

Objectives: To investigate the relationship between the metabolic activation enzyme cytochrome P4501A1 gene (CYP1A1) polymorphism and lung cancer in the Chinese population. Methods: Case-control study was used to investigate the distribution frequencies of the CYP1A1 polymorphic genotypes in 98 lung cancer patients and 98 healthy subjects and analyze the relationship between gene polymorphism a...

The aryl hydrocarbon receptor (AHR) and the a-class hypoxia inducible factors (HIF1a, HIF2a, and HIF3a) are basic helix-loop-helix PAS (bHLH-PAS) proteins that heterodimerize with ARNT. In response to 2,3,7,8-tetrachlorodibenzo-p-dioxin, the AHRzARNT complex binds to “dioxin responsive enhancers” (DREs) and activates genes involved in the metabolism of xenobiotics, e.g. cytochrome P4501A1 (Cyp1...

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants; a number are carcinogenic. Metabolic polymorphisms may modulate susceptibility to PAH-induced DNA damage and carcinogenesis. This study investigates the relationship between PAH-DNA adduct levels (in maternal and newborn WBCs) and two polymorphisms: (a) an MspI RFLP in the 3' noncoding region of cytochrome P4501A1 ...

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that can be activated by a diverse synthetic and naturally-occurring chemicals, such as the halogenated aromatic hydrocarbons (HAHs) and the non-halogenated polycyclic aromatic hydrocarbons (PAHs). The liganded AHR modulates the genetic activity of a variety of xenobiotic-responsive genes, including cytochrome P4501A...