Koronavirüs hastal??? (COVID-19) 2019 y?l?nda ilk olarak Çin'in Wuhan kentinde görülmü?, ard?ndan Dünya Sa?l?k Örgütü (WHO) taraf?ndan, yüksek ölüm oranlar?yla, pandemi ilan edilmi?tir. Bunun tüm Dünya’da ve ülkemizde ba?ta sa?l?k çal??anlar? olmak üzere risk alt?ndaki bireylerin korunmas?yla ilgili h?zla birçok kaynaktan çe?itli bilgiler payla??lmaya ba?lan?lm??t?r. COVID-19 pandemisi teorik e...

We recently reported that activation of the highly efficient phospholipase C (PLC) stimulatory m3 muscarinic acetylcholine receptor (mAChR) can induce a long-lasting Gi-mediated heterologous potentiation of PLC stimulation in human embryonic kidney (HEK) 293 cells, which was accompanied by an increased cellular level of the PLC substrate phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2]. He...

High NaCl in the renal medullary interstitial fluid powers the concentration of urine but can damage cells. The transcription factor nuclear factor of activated T cells 5 (NFAT5) activates the expression of osmoprotective genes. We studied whether PKC-α contributes to the activation of NFAT5. PKC-α protein abundance was greater in the renal medulla than in the cortex. Knockout of PKC-α reduced ...

AIMS Insulin (Ins) resistance (IRES) associates to increased cardiovascular risk as observed in metabolic syndrome. Chronic stimulation of beta-adrenergic receptors (betaAR) due to exaggerated sympathetic nervous system activity is involved in the pathogenesis of IRES. The cellular levels of G protein coupled receptor kinase 2 (GRK2) increase during chronic betaAR stimulation, leading to betaAR...

PURPOSE Somatostatin receptor (sst) targeting is an established method to image and treat sst-positive tumors. Particularly, neuroendocrine tumors express the receptor subtype 2 in high density, but sst1, sst3, sst4, and sst5 are also expressed to some extent in different human tumors. Currently used targeting peptides mainly have sst2 affinity. We aimed at developing (radio)peptides that bind ...

Absorption of riboflavin is mediated by transporter(s). However, a mammalian riboflavin transporter has yet to be identified. In the present study, the novel human and rat riboflavin transporters hRFT1 and rRFT1 were identified on the basis of our rat kidney mRNA expression database (Horiba N, Masuda S, Takeuchi A, Saito H, Okuda M, Inui K. Kidney Int 66: 29-45, 2004). hRFT1 and rRFT1 cDNAs hav...

Kim EY, Choi K-J, Dryer SE. Nephrin binds to the COOH terminus of a large-conductance Ca -activated K channel isoform and regulates its expression on the cell surface. Am J Physiol Renal Physiol 295: F235–F246, 2008. First published May 14, 2008; doi:10.1152/ajprenal.00140.2008.—We carried out a yeast two-hybrid screen to identify proteins that interact with large-conductance Ca -activated K (B...