نتایج جستجو برای: سلولهای t مهندسی شده car t cell
تعداد نتایج: 2678626 فیلتر نتایج به سال:
6 R of remarkable response rates and long-lasting remissions are beginning to emerge from clinical trials of chimeric antigen receptor (CAR) T cells in patients with B cell malignancies. However, the promising therapy is out of reach for patients who lack sufficient T cells for CAR T cell generation or cannot afford to forgo treatment for the time it takes to generate CAR T cells. To sidestep t...
PURPOSE The adoptive transfer of T cells modified to express a chimeric antigen receptor (CAR) comprised of an extracellular single-chain antibody (scFV) fragment specific for a tumor cell surface molecule, and linked to an intracellular signaling module, has activity in advanced malignancies. The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a tumor-associated molecule expressed in...
Adoptive cell therapy with chimeric antigen receptor (CAR)-engineered T cells is under investigation as an approach to restore productive T cell immunosurveillance in patients with pancreatic ductal adenocarcinoma. Early findings demonstrate safety of this cell-based therapy and the capacity of CAR-expressing T cells to mediate anti-tumor activity as well as induce endogeneous antitumoral immun...
Adoptive therapy of cancer with genetically redirected T cells showed spectacular efficacy in recent trials. A body of pre-clinical and clinical data indicate that young effector and central memory T cells perform superior in a primary anti-tumor response; repetitive antigen engagement, however, drives T cell maturation to terminally differentiated cells associated with the loss of CCR7 which e...
Chimeric antigen receptors (CAR) combine an antigen-binding domain with a CD3-zeta signaling motif to redirect T-cell specificity to clinically important targets. First-generation CAR, such as the CD19-specific CAR (designated CD19R), may fail to fully engage genetically modified T cells because activation is initiated by antigen-dependent signaling through chimeric CD3-zeta, independent of cos...
Chimeric antigen receptors (CARs) are versatile synthetic receptors that provide T cells with engineered specificity. Clinical success in treating B-cell malignancies has demonstrated the therapeutic potential of CAR-T cells against cancer, and efforts are underway to expand the use of engineered T cells to the treatment of diverse medical conditions, including infections and autoimmune disease...
New treatments are needed for B-cell malignancies persisting after allogeneic hematopoietic stem cell transplantation (alloHSCT). We conducted a clinical trial of allogeneic T cells genetically modified to express a chimeric antigen receptor (CAR) targeting the B-cell antigen CD19. T cells for genetic modification were obtained from each patient's alloHSCT donor. All patients had malignancy tha...
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