The RNASEL gene, a strong candidate for the hereditary prostate cancer 1 allele (HPC1), encodes a single-stranded specific endoribonuclease involved in the antiviral actions of IFNs. RNase L is activated enzymatically after binding to unusual 5'-phosphorylated, 2',5'-linked oligoadenylates (2-5A). Biostable phosphorothioate analogues of 2-5A were synthesized chemically and used to study the eff...

Protein kinase D (PKD) has been implicated in many aspects of tumorigenesis and progression, and is an emerging molecular target for the development of anticancer therapy. Despite recent advancement in the development of potent and selective PKD small molecule inhibitors, the availability of in vivo active PKD inhibitors remains sparse. In this study, we describe the discovery of a novel PKD sm...

BACKGROUND Prostate cancer (PCa) is a leading cause of cancer-related death in men. Sodium phenylbutyrate (SPB) has shown its potential as an anticancer therapy in numerous cancer types. In the present study, we attempted to assess the effect of SPB against PCa and whether this treatment was associated with the regulation of survivin. METHODS Two human PCa cancer cell lines, DU145 and PC3, we...

Prostate cancer (PCa) is associated with chronic prostate inflammation resulting in activation of stress and pro-survival pathways that contribute to disease progression and chemoresistance. The stress oncoprotein lens epithelium-derived growth factor p75 (LEDGF/p75), also known as DFS70 autoantigen, promotes cellular survival against environmental stressors, including oxidative stress, radiati...

كچ ي هد فده و هقباس : شبات ،هتشذگ ههد لوط رد ناديم زا يشان يريگ نتنآ زا لصاح يسيطانغمورتكلا ياه هدـنريگ ياه / ت هدنتسرف تسا هتفاي شيازفا هارمه نفل . هعلاطم نيا In vivo جاوما رثا يسررب روظنم هب 950 نـفلت متسيس زترهاگم هارمه GSM ينلاوط تيوقت رب تدم ) LTP ( هيحان Dentate gyrus تفرگ تروص . شور و داوم اه : 32 ر أ داژن زا ركذم يهاگشيامزآ گرزب شوم س Wistar دودح ينس اب 3 نزو و هام 15 ± 220 ـ گ ،مر...

Halophilic archaea are known as the novel producers of natural products and their supernatant metabolites could have cytotoxic effects on cancer cells. In the present study, we screened the anticancer potential of supernatant metabolites from eight native haloarchaeal strains obtained from a culture collection in Iran. Five human cancer cell lines including breast, lung, prostate and also human...

* نسيون لوئسم هد : نارهت ، و تمه عطاقت هاگشناد ،نارمچ ،يكــ شزپ هدكشــ ناد ،نارــ يا يكــ شزپ موــ لع هاگشــ يامزآ يميشويب نفلت : 88058742 email: [email protected] فده و هنيمز : ياهديسا رد هنيمآ تظلغ مسيناگراوركيم دشر رب يتوافتم تارثا فلتخم ياه يمامت دننامه و دنراد اه يتظلغ رد داوم صاخ دشر يارب مسيناگراوركيم تظلغ رد اما مزلا يم يمس رتلااب ياه دنشاب . عون هب هتسب ريداقم نيا دوب ده...

كچ ي هد فده و هقباس : ي ک ي طقس زورب للع زا اه ي ،ررکم ا لماوع تلاخد ي ژولونوم ي ک ا رد ي ن قم طققس عون ي وراد دقشاب ي س ي روپسولک ي ،ن ح لدم رد طقس شهاک بجوم ي ناو ي CBA/j×DBA/2 م ي تنآ ددرگ ي داب ي اه ي ان و راققتم TGF-β لماوع زا عت مهم يي ن گلماح تشونرس هدننک ي سررب روظنم هب رضاح هعلاطم تسا ي ات ث ي ر اس ي روپسولک ي ن م رب ي از ا ي ن تنآ عون ي داب ي س و اه ي اکوت ي ن TGF...

The prognosis for advanced prostate carcinoma (PCa) remains poor due to development of therapy resistance, and new treatment options are needed. Shikonin (SHI) from Traditional Chinese Medicine has induced antitumor effects in diverse tumor entities, but data related PCa scarce. Therefore, the parental (=sensitive) docetaxel (DX)-resistant cell lines, PC3, DU145, LNCaP, 22Rv1 were exposed SHI [...

شور و داوم اه : 35 عون يتبايد 2 نس اب 9 ± 54 لاس ) درم و نز ( دروم روكوس ود ينيلاب يئامزآ راك دراو و باختنا يدهاش 2 دندش ههام . دعب هرود زا 2 هتفه ناراميب ،نپوكيل يئاذغ عبانم فرصم عنم اب يزاسكاپ يا 8 هتفه نپوكيل لمكم هدننك تفايرد هورگ ود هب ) mg/d 10 ) ( 16 = n ( اي وبسلاپ ) 19 = n ( دندش ميسقت . رد هك دش هداد شزومآ ناراميب هب دنهدن رييغت ار دوخ يندب تيلاعف و يئاذغ ميژر ناكمالاا يت...