Brands, Michael W., Sharyn M. Fitzgerald, William H. Hewitt, and Allison E. Hailman. Decreased cardiac output at the onset of diabetes: renal mechanisms and peripheral vasoconstriction. Am J Physiol Endocrinol Metab 278: E917– E924, 2000.—Recently we reported that hindquarter blood flow, measured 24 h/day, decreased progressively over the first 6 days of type 1 diabetes in rats. That response, ...

The mechanistic understanding of interactions between diet-derived substances and conventional medications in humans is nascent. Most investigations have examined cytochrome P450–mediated interactions. Interactions mediated by other phase I enzymes are understudied. Aldehyde oxidase (AO) is a phase I hydroxylase that is gaining recognition in drug design and development programs. Taken together...

Constraint query languages are natural extensions of relational database query languages. A framework for their declarative speciication (constraint calculi) and eecient implementation (low data complexity and secondary storage indexing) was presented in Kanellakis et al., 1995. Constraint query algebras form a procedural language layer between high-level declarative calculi and low-level index...

Gloss, Bernd, Sonia Villegas, Francisco J. Villarreal, Anselmo Moriscot, and Wolfgang H. Dillmann. Thyroid hormone-induced stimulation of the sarcoplasmic reticulum Ca21 ATPase gene is inhibited by LIF and IL-6. Am J Physiol Endocrinol Metab 278: E738–E743, 2000.—We investigated the effects of the leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) on 3,38, 5-triiodo-L-thyronine, or thyro...

Metges, Cornelia C., Yong-Ming Yu, Wei Cai, XiaoMing Lu, Sue Wong, Meredith M. Regan, Alfred Ajami, and Vernon R. Young. Oxoproline kinetics and oxoproline urinary excretion during glycineor sulfur amino acid-free diets in humans. Am J Physiol Endocrinol Metab 278: E868–E876, 2000.—L-5-oxoproline (L-5-OP) is an intermediate in glutathione synthesis, possibly limited by cysteine availability. Ur...

Abely, M., P. Dallet, M. Boisset, and J. F. Desjeux. Effect of cholera toxin on glutamine metabolism and transport in rabbit ileum. Am J Physiol Gastrointest Liver Physiol 278: G789–G796, 2000.—The aim of the present study was to evaluate the effect of cholera toxin on energy balance from intestinal glutamine metabolism and oxidation, glutaminedependent sodium absorption, and cholera toxin-depe...

CARMEN ALVAREZ,1,2 DANIELLE BAILBE,1 FRANÇOISE PICAREL-BLANCHOT,1 ERIC BERTIN,1 ANA-MARIA PASCUAL-LEONE,2 AND BERNARD PORTHA1 1Laboratoire Physiopathologie de la Nutrition, Centre National de la Recherche Scientifique Enseignement Supérieur Associé 7059, Université Paris, 75251 Paris, France; and 2Instituto de Bioquimica-Centro Mixto Universite Complutense y Consejo Superior Investigaciones Cie...

Oates, Phillip S., Carla Thomas, Elizabeth Freitas, Matthew J. Callow, and Evan H. Morgan. Gene expression of divalent metal transporter 1 and transferrin receptor in duodenum of Belgrade rats. Am J Physiol Gastrointest Liver Physiol 278: G930–G936, 2000.—Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (...

Graham, T. E., V. Sgro, D. Friars, and M. J. Gibala. Glutamate ingestion: the plasma and muscle free amino acid pools of resting humans. Am. J. Physiol. Endocrinol. Metab. 278: E83–E89, 2000.—Monosodium glutamate (MSG) ingestion is known to increase plasma glutamate concentration, and MSG infusion stimulates insulin secretion. We investigated the impact of MSG ingestion on both the plasma and i...