75Se-Labeled tRNAs were synthesized by Clostridium sticklandii cultures supplemented with 1 microM sodium [75Se]selenite or [75Se]selenocysteine. This process is highly specific for selenium; it occurred in the presence of 1.2 mM sodium sulfide and was not decreased by the further addition of a 500-fold molar excess of cysteine. The 75Se in these tRNAs was located in the polynucleotide portion ...

Partially purified thrombopoiesis-stimulating activity was prepared from the plasma of thrombocytopenic rabbits using ammonium sulfate precipitation and DEAE cellulose, Sephadex, and carboxymethyl cellulose chromatography. The protein fraction precipitated by an ammonium sulfate saturation of 60%-80%, previously shown to contain thrombopoiesis-stimulating activity, was used as starting material...

The brain is a network and our intelligence depends in part on the efficiency of this network. The network of adolescents differs from that of adults suggesting developmental changes. However, whether the network changes over time at the individual level and, if so, how this relates to intelligence, is unresolved in adolescence. In addition, the influence of genetic factors in the developing ne...

Effective flow feature extraction enables users to explore complex flow fields by reducing visual clutter. Existing methods usually use streamline segmentation as a preprocessing step for feature extraction. In our work, features are directly extracted as a result of streamline segmentation. In order to achieve this, we first ask users to specify desired features by manually segmenting a few st...

The application of state-of-the-art history matching methods to large heterogeneous reservoirs is hampered by two main problems: (1) reservoir models should be constrained jointly to dynamic data and a large variety of geological continuity information, (2) CPU demand should not be prohibitive for large models. This paper proposes a method contributing to alleviating these two main concerns. By...

To analyze and understand the growing wealth of scientific data, complex workflows need to be assembled, often requiring the combination of looselycoupled resources, specialized libraries, distributed computing infrastructure, and Web services. However, constructing these workflows is a non-trivial task, especially for users who do not have programming expertise. This problem is compounded for ...

Curves in space are diicult to perceive and analyze, especially when they form dense sets as in typical 3D ow and volume deformation applications. We propose a technique that exposes essential properties of space curves by attaching an appropriate moving coordinate frame to each point, reexpressing that moving frame as a unit quaternion, and supporting interaction with the resulting quaternion ...

In the first study, Dr. Alexander Lembcke and colleagues at Charitè Medical University in Berlin compared a lowand a standard-dose contrast protocol in 60 consecutive patients with body weights ranging from 60 to 80 kg. Thirty of them received a 35-mL dose of contrast injected at 7.5 mL/sec (group A), while the remainder got a 70-mL dose injected at 5 mL/sec (group B). All patients underwent au...

The last decade in oncology has been marked by the identification of numerous new potential cancer targets and even more agents designed to inhibit them. The matrix of new targets, new agents, and the companion diagnostics required to identify the right patient for the right drug has created a major challenge for the clinical trial process. This has been compounded by the addition of new immuno...