Pax-5 codes for the transcription factor BSAP, which plays an important role in midbrain patterning, B cell development, and lymphoma formation. Pax-5 is known to control gene expression by recognizing its target genes via the NH2-terminal paired domain and by regulating transcription through a COOH-terminal regulatory module consisting of activating and inhibitory sequences. The central region...

Metastatic melanoma is an aggressive cancer with very low response rate against conventional chemotherapeutic agents such as dacarbazine (DTIC). Inhibitor of Rb-Raf-1 interaction RRD-251 was tested against the melanoma cell lines SK-MEL-28, SK-MEL-5, and SK-MEL-2. RRD-251 was found to be a potent inhibitor of melanoma cell proliferation, irrespective of V600E B-Raf mutation status of the cell l...

Metastatic melanoma is an aggressive cancer with very low response rate against conventional chemotherapeutic agents such as dacarbazine (DTIC). Inhibitor of Rb–Raf-1 interaction RRD-251 was tested against the melanoma cell lines SK-MEL-28, SK-MEL-5, and SK-MEL-2. RRD-251 was found to be a potent inhibitor of melanoma cell proliferation, irrespective of V600E B-Raf mutation status of the cell l...

Here, we report the enhanced upconversion luminescence of NaLuF4:18%Yb(3+),2%Er(3+) through core/shell structures. Among NaYF4, NaGdF4, and NaLuF4 shells, the first one presents the highest efficiency. These upconversion fluorescent nanoprobes with an oleic acid/PEG hybrid ligand can efficiently capture Rhodamine B (RB) and sodium fluorescein (SF) in opaque fishes to present their residues in v...

The present work aims to investigate the removal of dye Rhodamine-B (RB) and Congo red (CR) dye from aqueous solutions by low cost bio-waste adsorbents, such as Maranta arundinacea activated carbon (MAC) under various experimental conditions. The effect of dye concentrations, contact time, temperature and adsorbent dose on the removal of dyes was studied. The kinetic experimental data were fitt...

BACKGROUND Likelihood-based methods can work poorly when the residuals are not normally distributed and the variances across clusters are heterogeneous. METHOD The performance of two estimation methods, the non-parametric residual bootstrap (RB) and the restricted maximum likelihood (REML) for fitting multilevel models are compared through simulation studies in terms of bias, coverage, and pr...

Rayleigh-Brillouin (RB) scattering profiles for air have been recorded for the temperature range from 255 to 340 K and the pressure range from 640 to 3300 mbar, covering the conditions relevant for the Earth's atmosphere and for planned atmospheric light detection and ranging (LIDAR) missions. The measurements performed at a wavelength of λ=366.8 nm detect spontaneous RB scattering at a 90° sca...

Aim of this study was to evaluate the differences in Ca, P, K, Na, Mg, Zn, Fe, Cu, Mn, Se, Mo, Co, Li, B, Ti, Rb, and Sr concentrations milk from buffaloes cows reared same farm Mediterranean areas fed diets including ingredients. Individual samples were obtained 32 29 Italian Friesian milk, dietary ingredients drinking water analyzed for investigated chemical elements by inductively coupled pl...

We survey the implications for new physics of the discrepancy between the LEP measurement of Rb and its Standard Model prediction. Two broad classes of models are considered: (i) those in which new Zbb couplings arise at tree level, through Z or b-quark mixing with new particles, and (ii) those in which new scalars and fermions alter the Zbb vertex at one loop. We keep our analysis as general a...