Immunohistochemical expression of MAGE-A1, MAGE-A3/4 and NY-ESO-1/LAGE-1 cancer testis antigens (CTA) was assessed in 24 fetal testes from 15th to 36th week of gestation. Three monoclonal antibodies were used for immunohistochemical staining: 77B recognizing MAGE-A1, 57B recognizing multiple MAGE-A CTA, and D8.38 recognizing NY-ESO-1/LAGE-1. Expression of MAGE-A1 was not observed in fetal testi...

This paper presents an ESO-based iPI control for common rail pressure. First, a detailed mathematical model of High Pressure Common Rail Injection System (HPCRIS) is built. The mathematical model is validated by the software Matlab and commercial software AMESim. For the considered HPCRIS, an effective model free controller which is called Extended State Observer based intelligent Proportional ...

Consider decision problems derived from optimization problems. For problems in this category, we show that they cannot be expressed in existential second order (ESO) logic with a first order part that is universal Horn (or simply, ESO Π1 Horn) at the structure level, as opposed to machine level. This is true even when we consider ordered structures. We show that an NP-complete problem (Maximum ...

In October 1997, the Italian and Dutch GRB teams started a collaboration on ESO optical follow-up of rapidly and accurately localized GRBs. Subsequently, starting April 1, 2000, this collaboration was extended to astronomers from other countries, who contributed their expertise for the creation of a Consortium committed to the study of GRB counterparts and host galaxies at optical and near-infr...

NY-ESO-1-specific CD4(+) T cells are of interest for immune therapy against tumors, because it has been shown that their transfer into a patient with melanoma resulted in tumor regression. Therefore, we investigated how NY-ESO-1 is processed onto MHC class II molecules for direct CD4(+) T cell recognition of melanoma cells. We could rule out proteasome and autophagy-dependent endogenous Ag proc...

The existence of overlapping CD8+ and CD4+ T-cell epitopes within certain tumor antigens provides an opportunity to test the hypothesis that relatively short peptides could be used to generate both CD8+ and CD4+ T cells against tumor. In this report, T-cell responses to a fragment of the tumor antigen NY-ESO-1 that contained an HLA-DP4-restricted helper T cell epitope as well as an HLA-A2-restr...

in recent year, the evolutionary structural optimization (eso) method, has been applied as an effective tool for structures design. the concept of eso method is to use the finite element  results in each iteration of process and removal of inefficient material based on these results. in this method there are several experimental parameters such as rejection rate and evolutionary rate that are e...