After exocytosis, synaptic vesicles are recycled locally in the synaptic terminal and are refilled with neurotransmitter via vesicular transporters. The biophysical mechanisms of refilling are poorly understood, but it is clear that the generation of a proton gradient across the vesicle membrane is crucial. To better understand the determinants of vesicle refilling, we developed a novel method ...

Case Reports Case 1, a male, aged 52, had had a right macular haemorrhage about 20 years previously, and for a period of 4 months had noticed deterioration of the visual acuity of the left eye. The right eye showed a posterior staphyloma and advanced macular degeneration typical of myopia; the left eye had a central retinal detachment occupying the area of a posterior staphyloma (Fig. 1). The v...

INTRODUCTION Sinistral, or left-sided, portal hypertension (SPH) is a rare entity, with multiple potential causes. Gastrointestinal variceal bleeding and hypersplenism are its' major clinical manifestations. The main aim of the present study is to summarize the clinical features of patients with SPH. PATIENTS AND METHODS This was a retrospective analysis of consecutive patients with present o...

The work, results, and thoughts of Andrija Štampar are recognized globally as a public health heritage (1). They encompass the vision of health as a state of overall well-being, society as the key responsible health care provider, and a set of values and guiding principles underlining the importance of optimal health. The reasons behind their adoption worldwide lie in the success of public heal...

This paper presents the first method for isosurface extraction from smoothed particle hydrodynamics (SPH) data that is exact with respect to the functional representation provided by SPH. The Marching Correctors algorithm is an extension of the Marching Cubes algorithm which is adapted to the SPH representation and avoids resampling to a full grid. The algorithm operates on a virtual grid of su...

Over a century has passed since slavery was abolished in Brazil, yet quilombola communities remain socially vulnerable, especially when it comes to health. The goal of this study was to understand self-perceived health (SPH) in quilombola communities in Northern Minas Gerais, and the factors associated with their negative -perceived their own health. A household survey of a representative sampl...

Activation of the PDGF receptor on human arterial smooth muscle cells (SMC) induces migration and proliferation via separable signal transduction pathways. Sphingosine-l-phosphate (Sph-l-P) can be formed following PDGF receptor activation and therefore may be implicated in PDGF-receptor signal transduction. Here we show that Sph-l-P does not significantly affect PDGF-induced DNA synthesis, prol...

Spectrin and protein 4.1R crosslink F-actin, forming the membrane skeleton. Actin and 4.1R bind to one end of β-spectrin. The adjacent end of α-spectrin, called the EF domain, is calmodulin-like, with calcium-dependent and calcium-independent EF hands. The severely anemic sph(1J)/sph(1J) mouse has very fragile red cells and lacks the last 13 amino acids in the EF domain, implying that the domai...