This study investigated the in vitro activity of gemifloxacin (SB-265805) against 50 recent clinical isolates of Streptococcus pyogenes, Streptococcus agalactiae and viridans streptococci using the microdilution method. This activity was compared with that of the quinolone agents ofloxacin, ciprofloxacin, levofloxacin, trovafloxacin and grepafloxacin, and with that of penicillin, ampicillin, cl...

Sixty recent Streptococcus pneumoniae isolates with different susceptibilities to ciprofloxacin (14 with MIC 0.5 mg/L, 10 with MIC 1 mg/L, eight with MIC 2 mg/L, 11 with MIC 4 mg/L and 17 with MIC > or =8 mg/L) were tested against five new quinolones using Todd-Hewitt broth with and without 80% serum. The final inoculum was 5 x 10(5) cfu/mL. Gemifloxacin and clinafloxacin exhibited the lowest M...

BACKGROUND One of the anatomic structures in the mental interforaminal area is the mandibular incisive canal (MIC). Using various manipulation tools in the digital system may affect the visibility of MIC. OBJECTIVES The purpose of this study was to assess the effect of inversion filter (IF) on the visibility of mandibular incisive canal in panoramic radiographs. PATIENTS AND METHODS In this...

Ceftaroline, the active metabolite of the prodrug ceftaroline fosamil, is a broad-spectrum cephalosporin with bactericidal activity against resistant Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA), and common Gram-negative organisms. We evaluated the activity of ceftaroline and various antimicrobial agents against S. aureus isolates according to patient ag...

Two hundred fifty isolates of Mycobacterium tuberculosis were evaluated for susceptibility to ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin, and gemifloxacin (SB-265805). Levofloxacin, ciprofloxacin, and grepafloxacin showed the greatest activity (MIC for 90% of strains tested [MIC(90)] 1 microg/ml), although ofloxacin also showed good activity, with an MIC(90) of 2 micro...

We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a MIC of ≤ 2 mg/liter than for isolates with a higher MIC (0% versus 41.1%; P = 0...

Applying for information theory, we present a measure of dependence for three-variable relationships: the three variables maximal information coefficient (3D-MIC). It is a kind of maximal information-based nonparametric exploration (MINE) statistics for identifying and classifying relationships in large data sets. 3D-MIC generalized the MIC measurement. At the same time some optimal single axis...

Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 μg/mL) than other compounds. Thi...

A n t i f u n g a l a c t i v i t y o f r h e i n ( 1 , 8 dihydroxyanthraquinone3carboxylic acid) isolated from the ethyl acetate extract of Cassia fistula flower was studied. Rhein inhibited the growth of many fungi such as Trichophyton mentagrophytes (MIC 31.25 μg/ml), Trichophyton simii (MIC 125 μg/ml), Trichophyton rubrum (MIC 62.5 μg/ml) and Epidermophyton floccosum (MIC 31.25 μg/ml).

Since the disaster in Bhopal, India, people exposed to methyl isocyanate (MIC) have complained of various disorders including neuromuscular dysfunction. In an attempt to get information about such dysfunction we have previously shown that MIC can affect muscle cells in culture. The present communication reports investigations into the effect of MIC on brain cells in culture. MIC was toxic to br...