نتایج جستجو برای: روش itd
تعداد نتایج: 371410 فیلتر نتایج به سال:
We investigated the role of GABAergic inhibition on the responses of inferior colliculus (IC) neurons sensitive to interaural time differences (ITDs) in anesthetized guinea pigs. Responses to static and dynamic ITDs were obtained before, during, and after recovery from ionotophoretic application of GABA, or antagonists to the GABA(A) receptor gabazine and bicuculline. For most neurons, a linear...
Acute myeloid leukemia (AML) with an FLT3 internal tandem duplication (FLT3-ITD) mutation is an aggressive hematologic malignancy with a grave prognosis. To identify the mutational spectrum associated with relapse, whole-exome sequencing was performed on 13 matched diagnosis, relapse, and remission trios followed by targeted sequencing of 299 genes in 67 FLT3-ITD patients. The FLT3-ITD genome h...
In acute myeloid leukemia (AML), further prognostic determinants are required in addition to cytogenetics to predict patients at increased risk of relapse. Recent studies have indicated that an internal tandem duplication (ITD) in the FLT3 gene may adversely affect clinical outcome. This study evaluated the impact of a FLT3/ITD mutation on outcome in 854 patients, mostly 60 years of age or youn...
BACKGROUND When a second sound follows a long first sound, its location appears to be perceived away from the first one (the localization/lateralization aftereffect). This aftereffect has often been considered to reflect an efficient neural coding of sound locations in the auditory system. To understand determinants of the localization aftereffect, the current study examined whether it is induc...
PURPOSE FMS-like tyrosine kinase-3 (FLT3) internal tandem duplication (FLT3-ITD) mutations are common in patients with acute myeloid leukemia (AML). These patients regularly develop resistance to FLT3 inhibitors suggesting that targeted combination drug strategies are needed to enhance AML therapy efficacy. EXPERIMENTAL DESIGN Acquired point mutations of FLT3-ITD gene were screened using cDNA...
In the July 1, 2006, issue of Blood, Meshinchi et al1 comment on the role of stem-cell transplantation (SCT) in FLT3/ITD-positive acute myeloid leukemia (AML). In their interpretation of data previously presented by Gale et al,2 they conclude that the occurrence of a FLT3/ITD may not be regarded as a negative prognostic factor in patients undergoing allogeneic SCT. The dispute between both auth...
The presence of internal tandem duplications (ITD) in the Fms-related tyrosine kinase 3 receptor (FLT3) has been associated with a poor prognosis in acute myeloid leukemia (AML). Over the past decade, FLT3 is a promising target in FLT3-ITD-positive AML. Sorafenib which is one of the commonly focused FLT3 inhibitors may improve outcome, but only few patients display long-term responses in previo...
An inspiratory impedance threshold device (ITD) has recently been demonstrated to enhance vital organ perfusion and neurologically intact survival rates in animals in cardiac arrest during standard cardiopulmonary resuscitation (CPR) (1– 4). The ITD is a small, 35-mL device that can attach to a variety of airway adjuncts, including a facemask and endotracheal tube (Fig. 1). By selectively imped...
Deep Learning can significantly benefit cancer proteomics and genomics. In this study, we attempt to determine a set of critical proteins that are associated with the FLT3-ITD mutation in newly-diagnosed acute myeloid leukemia patients. A Deep Learning network consisting of autoencoders forming a hierarchical model from which high-level features are extracted without labeled training data. Dime...
A novel extension to recurrent timing neural networks (RTNNs) is proposed which allows such networks to exploit a joint interaural time difference-fundamental frequency (ITD-F0) auditory cue as opposed to F0 only. This extension involves coupling a second layer of coincidence detectors to a two-dimensional RTNN. The coincidence detectors are tuned to particular ITDs and each feeds excitation to...
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