Context. The majority of the intermediate mass, pre-main-sequence Herbig Ae/Be stars reside in binary systems. As these systems are young, their properties may contain an imprint of the star formation process at intermediate masses (2-15 M⊙). However, these systems are generally spatially unresolved, making it difficult to probe their circumstellar environment to search for manifestations of th...

Hereditary and acquired angioedema are potentially life-threatening diseases characterized by spontaneous episodes of subcutaneous and submucosal swelling of face, lips, oral cavity, larynx, and GI tract. Hereditary angioedema (HAE) usually presents within the first and second decades of life, whereas acquired angioedema presents in adults after 40 years of age. These clinical symptoms together...

We report an approximately 80% reduction in angioedema attacks with lanadelumab, a mAb targeting plasma kallikrein, case of hereditary normal C1 inhibitor levels. This finding supports central pathophysiologic role for kallikrein levels and the need prospective studies lanadelumab use this condition. Hereditary (HAE) is rare genetic condition characterized by recurrent cutaneous submucosal swel...

Background Hereditary angioedema (HAE) types I and II (due to quantitative and qualitative C1-INH deficiency, respectively) is a rare autosomal dominant condition in which more than 300 different mutations in the entire C1-INH gene (SERPING1) have been described. The objective of this study is to identify and characterize the mutation in the SERPING1 gene in a family of HAE outpatients from the...

Abstract As electricity market reforms continue and households consume more electricity, Household Electricity Response (HER) becomes an essential part of Demand (DR). The ability to adjust their demand is a critical factor in evaluating the demand-side response capacity power systems. Therefore, prediction method household adjustable (HAE) based on cross-domain generalization proposed solve pr...

Several types of angioedema exist beyond hereditary angioedema (HAE) types I/II; however, the diagnostic and treatment needs of these conditions are not well understood. Noticeably, there are no licensed treatments available for other forms of angioedema beyond HAE types I/II, and similarly they are unresponsive to conventional antihistamine/glucocorticoid treatment. A group of angioedema exper...

Hereditary angioedema (HAE) due to C1-inhibitor de ciency is a rare autosomal dominant disease characterized by recurrent episodes of transient localized swelling of the subcutaneous and/or mucosal tissues that can occur anywhere in the body. Acute abdominal pain due to mucosal swelling of the gut is one of the most common presentations of HAE, leading frequently to unnecessary abdominal surger...

Highly purified and radioiodinated human C4 and (or) C3 were administered to patients with renal allografts in rejection, with hereditary angioedema (HAE), with chronic glomerulonephritis, and to control subjects. The latter group included normal individuals, anephric patients before transplantation, and stable renal allograft recipients. The catabolic rates of these complement proteins were de...

Hereditary angioedema (HAE) is caused by a deficiency in C1 esterase inhibitor and is characterized by sudden attacks of edema associated with discomfort and pain. The disease places patients at risk for disability and death if left untreated. Symptom severity and frequency can be extremely variable even among affected members of the same family. Attacks are not associated with inflammation or ...

Hereditary (HAE) and acquired (AAE) angioedema are vascular reactions involving the sub mucosal tissues, representing localized edema caused by dilatation and increased permeability of the capillaries. HAE and AAE are clinical disorders characterized by angioedema that require prompt differentiation from other causes of angioedema in order to receive the most pertinent and effective therapeutic...