Autophagy is a cellular bulk degradation pathway implicated in various diseases. Inhibition of autophagy has been regarded as a new therapeutic strategy for cancer treatment, especially in combination with chemotherapy. In our study, we identified two natural compounds, dauricine (DAC) and daurisoline (DAS), as two potent autophagy blockers through a high-content screening. DAC and DAS are alka...

Es wird ein marginalisiertes Partikelfilter beschrieben, das zur einkanaligen Sprachsignalverbesserung mit einem nichtlinearen dynamischen Zustandsmodell eingesetzt werden soll. Das System besteht aus einem Partikelfilter zum Tracking von LSP-Parametern und einem Kalman-Filter für jedes Partikel, das zur Sprachsignalverbesserung verwendet wird. In unserem Ansatz wird angenommen, dass die Parame...

Zusammenfassung: IT-Sicherheit ist für Unternehmen von elementarer Bedeutung. Im IT-Sicherheitsmanagement werden Techniken entwickelt, mit denen die Sicherheit von Informationssystemen gewährleistet werden soll. Aktuelle Studien zeigen, dass der überwiegende Teil von Betriebsstörungen auf menschliches (Fehl)Verhalten zurückzuführen ist. Daher erscheint es notwendig, das ITSicherheitsmanagement ...

The Distributed ASCI Supercomputer (DAS) Project has resulted in four generations of highly successful distributed clusters, starting with DAS-1 in 1997 leading up to DAS-4, which is expected to be installed mid-2010. Each new incarnation has implemented bold new technologies, pushing the limits of highperformance cluster design. Recent years have also seen the rise of the cloud computing parad...

abstract iris yellow spot virus (iysv) is one of the important pathogens of onion in reported countries. host range of this virus is very wide and transmitted by onion thrips (thrips tabaci). in survey that was conducted in summer 2006 in onion fields of mashhad, samples with viral symptoms and high population of thrips have been collected. since the symptoms were similar to iysv, special antis...

Allium vegetables have been shown to have beneficial health effects against several chronic diseases including cancer. Diallyl sulfide (DAS), an organosulfur compound present in garlic, is well known for its chemopreventive properties in several tumor models. The pharmacologic role of DAS in prevention and treatment of cancer is well documented in the literature, but its molecular mechanism of ...