BACKGROUND Emerging evidence suggests that "adaptive" induction of autophagy (the cellular process responsible for the degradation and recycling of proteins and organelles) may confer a cardioprotective phenotype and represent a novel strategy to limit ischemia-reperfusion injury. Our aim was to test this paradigm in a clinically relevant, large animal model of acute myocardial infarction. ME...

BACKGROUND Under conventional heart failure therapy, inflammatory cardiomyopathy typically has a progressive course, indicating a need for alternative therapeutic strategies to improve long-term outcomes. We recently isolated and identified novel cardiac-derived cells from human cardiac biopsies: cardiac-derived adherent proliferating cells (CAPs). They have similarities with mesenchymal stroma...

ID: 18837 Title: Improved Collimator Scattering Factor (Sc) Measurements for Small Fields Using Build-Up Caps in Robotic Radiosurgery Purpose:The Monte Carlo calculation algorithm in the MultiPlan (Accuray, Palo Alto, CA) treatment planning system used for CyberKnife (Accuray) robotic radiosurgery requires in-air measurements. In this study, results were compared for the impact of build-up caps...

Background CAPS is an orphan auto-inflammatory disease, generally diagnosed in childhood that requires life-long treatment. Canakinumab, a fully human anti-IL-1b antibody, has previously demonstrated rapid, complete and sustained response in CAPS patients. Aim To compare dosing patterns of canakinumab in pediatric and adult CAPS patients of a predominantly Western population (WP) vs Japanese pa...

We prove that 45 is the size of the largest caps in AG(5, 3), and such a 45-cap is always obtained from the 56-cap in PG(5, 3) by deleting an 11-hyperplane.

We obtain, in principle, a complete classification of all long inextendable binary linear codes. Several related constructions and results are presented.

Recall that a cap in PG(n, 2) is simply a set of points with no three collinear. A cap which intersected all codimension 2 subspaces would yield an interesting example of a 2-block: 2-blocks have been much studied in the literature. An interesting folklore conjecture, which received considerable attention, had it that in fact no cap is a 2-block. Although this conjecture can be shown to be true...

It is shown that, for solid caps D of heat balls in Rd+1 with center z0 = (0, 0), there exist Borel measurable functions w on D such that inf w(D) > 0 and ∫ v(z)w(z) dz ≤ v(z0), for every supertemperature v on a neighborhood of D. This disproves a conjecture by N. Suzuki and N.A. Watson. On the other hand, it turns out that there is no such volume mean density, if the bounded domain D in Rd × (...

A very difficult problem for complete caps in PG(r,q) is to determine their minimum size. The results on this topic are still scarce and in this paper we survey the best results now known. Furthermore, we construct new interesting sporadic examples of complete caps in PG(3, q) and in PG(4, q) such that their size are smaller than the currently known. As a consequence, we get that the Pellegrino...