Ischemic retinal diseases such as diabetic retinopathy, retinal vein occlusion, and retinopathy of prematurity may precipitate retinal neovascularization. Pathological retinal angiogenesis, in turn, may cause vitreous hemorrhage, retinal detachment, and/or neovascular glaucoma affecting vision. Among the many molecules produced by the hypoxic retina, vascular endothelial growth factor A (VEGFA)...

BACKGROUND Aedes albopictus is distributed widely in China, as a primary vector of Dengue fever and Chikungunya fever in south of China. Chemical insecticide control is one of the integrated programmes to prevent mosquito-borne diseases. Long-term applications of pyrethroids have resulted in the development of resistance in Ae. albopictus populations in China. However, the susceptibility of Ae....

BACKGROUND The angiogenic and invasive properties of the cytotrophoblast are crucial to provide an adequate area for feto-maternal exchange. The present study aimed at identifying the localization of interrelated angiogenic, hyperpermeability and vasodilator factors in the feto-maternal interface in pregnant guinea-pigs. METHODS Utero-placental units were collected from early to term pregnanc...

Abstract The redlegged earth mite, Halotydeus destructor , is an economically important pest of winter field crops and pastures in Australia, has evolved resistance to pyrethroid chemicals through a polymorphism the voltage-gated parasodium channel leading knockdown ( kdr) . In this study, we quantified rate reversion susceptibility partially resistant H. populations under conditions absence pe...

Pyrethroid resistance in three horn fly populations in Louisiana was monitored by weekly fly counts, filter paper bioassays, and diagnostic PCR assays for the presence of pyrethroid resistance-associated mutations in the sodium channel gene coding region. The PCR assay for the knockdown resistance (kdr) and superkdr sodium channel mutations was used to determine the frequency of the target site...

Background: Ongoing inflammatory processes resulting in airway and vascular remodelling characterise chronic obstructive pulmonary disease (COPD). Vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1) could play a role in tissue remodelling and angiogenesis in COPD. Methods: The cellular expression pattern of VEGF, Flt-1, and KDR/Flk-1 was examined ...

A new kernel dimension reduction (KDR) method based on the gradient space of canonical functions is proposed for sufficient dimension reduction (SDR). Similar to existing KDR methods, this new method achieves SDR for arbitrary distributions, but with more flexibility and improved computational efficiency. The choice of loss function in cross-validation is discussed, and a two-stage screening pr...