نتایج جستجو برای: دیگوکسین digoxin

تعداد نتایج: 3205  

Journal: :American journal of cancer therapy and pharmacology 2014
Jianqing Lin Tingting Zhan Danielle Duffy Jean Hoffman-Censits Deborah Kilpatrick Edouard J Trabulsi Costas D Lallas Inna Chervoneva Kimberly Limentani Brooke Kennedy Sarah Kessler Leonard Gomella Emmanuel S Antonarakis Michael A Carducci Thomas Force Wm Kevin Kelly

BACKGROUND Digoxin was found to inhibit prostate cancer (PCa) growth via the inhibition of HIF-1α synthesis in a mouse model. We hypothesized that a therapeutic dose of digoxin could inhibit human PCa growth and disease progression. METHODS An open label, single arm pilot study was performed. Patients (pts) with non-metastatic, biochemically relapsed PCa with prostate specific antigen doublin...

Journal: :Circulation research 1971
K H Prindle C L Skelton S E Epstein F I Marcus

Because of conflicting reports on the influence of extracellular potassium concentration ([K]o) on the inotropic action of cardiac glycosides, we compared the effects of varying [K]o (1.5, 4.5, and 7.5mM) on the inotropic action and myocardial concentration of tritiated digoxin (5 X 10~M) using the isolated cat papillary muscle. The time course of the inotropic response to digoxin was significa...

Journal: :American heart journal 1988
J J Lynch P J Simpson K P Gallagher T B McClanahan K A Lee B R Lucchesi

In the present study, dogs were pretreated with intravenous digoxin, 0.0125 mg/kg/day, for 6 to 7 consecutive days to achieve clinically relevant serum concentrations; untreated animals were used as control subjects. After pretreatment, nine digoxin-pretreated dogs and nine control dogs were anesthetized and subjected to a 60-minute occlusion of the left circumflex coronary artery, followed by ...

Journal: :British journal of clinical pharmacology 1997
D E Martin D Tompson S C Boike D Tenero B Ilson D Citerone D K Jorkasky

AIMS To study the effect of eprosartan, a nonbiphenyl tetrazole angiotensin II receptor antagonist, on digoxin pharmacokinetics in a randomized, open-label, two period, period balanced crossover study in 12 healthy men. METHODS Each subject received a single 0.6 mg oral dose of digoxin (Lanoxicaps 0.2 mg/capsule, Glaxo Wellcome) alone or following 4 days of dosing with eprosartan 200 mg orall...

Journal: :Pharmacoepidemiology and drug safety 2016
Reema A Karasneh Liam J Murray Carmel M Hughes Chris R Cardwell

PURPOSE Preclinical studies have shown that digoxin exerts anticancer effects on different cancer cell lines including prostate cancer. A recent observational study has shown that digoxin use was associated with a 25% reduction in prostate cancer risk. The aim of this study was to investigate whether digoxin use after diagnosis of prostate cancer was associated with decreased prostate cancer-sp...

2016
Soham Dasgupta Ashraf M. Aly Sunil K. Jain

Introduction Congestive heart failure due to left to right cardiac shunt is usually managed medically with diuretics, angiotensin converting enzyme inhibitors, and, in some cases, with the addition of digoxin. Case We report a 31-week gestation premature male infant who did not respond to such treatment and developed hyperaldosteronism and severe hypokalemia secondary to activation of the renin...

2015
Ying Chen Xiaoyan Cai Weijun Huang Yanxian Wu Yuli Huang Yunzhao Hu

Digoxin is still commonly used in atrial fibrillation (AF) patients with and without heart failure (HF) for heart rate control. Studies concerning the detrimental effects of digoxin therapy in AF patients are inconsistent. This updated meta-analysis examined the association of digoxin therapy with all-cause mortality in AF patients, stratified by heart function status. We included observational...

Journal: :The Journal of clinical investigation 1974
H Garan T W Smith W J Powell

Digitalis is known to have a vasoconstrictor effect in the coronary circulation. Recent studies have demonstrated that the coronary vasoconstrictor effects of acetylstrophanthidin and digoxin are neurally mediated via alpha adrenergic fibers. In the present study, experiments were done in 20 dogs anesthetized with chloralose and urethane to study the central nervous system as a possible site of...

Journal: :Journal of the American College of Cardiology 1984
K Nademanee R Kannan J Hendrickson M Ookhtens I Kay B N Singh

Administration of amiodarone (600 to 1,600 mg/day) to 28 patients during long-term digoxin therapy (0.25 +/- 0.05 mg/day) increased serum digoxin level from 0.97 +/- 0.45 to 1.98 +/- 0.84 ng/ml (p less than 0.001). Gastrointestinal side effects occurred in nine patients, central nervous system reactions occurred in five and cardiovascular reactions occurred in four. Pharmacokinetic studies in s...

Journal: :Clinical chemistry 1996
S A Jortani R A Helm R Valdes

Ingestion of oleander plant, containing the cardiac glycoside oleandrin, has been reported to induce fatal poisonings. Derivatives of oleandrin are structurally similar to digoxin. We investigated the cross-reactivities of oleandrin and its aglycone metabolite, oleandrigenin, in several commercially available digoxin immunoassays; assessed their ability to inhibit Na,K-ATPase catalytic activity...

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