A combination of fusion and surface adsorption techniques was used to enhance the dissolution rate of cefuroxime axetil. Solid dispersions of cefuroxime axetil were prepared by two methods, namely fusion method using poloxamer 188 alone and combination of poloxamer 188 and Neusilin US2 by fusion and surface adsorption method. Solid dispersions were evaluated for solubility, phase solubility, fl...

β-Tricalcium phosphate (β-TCP) is an attractive ceramic for bone tissue repair because of its similar composition to bone mineral and its osteoconductivity. However, compared with other ceramics β-TCP has a rapid and uncontrolled rate of degradation. In the current study β-TCP granules were mineral coated with the aim of influencing the dissolution rate of β-TCP, and also to use the coating as ...

Sub-micron sized alumina fibres were fabricated by electrospinning and calcination of a polymer template fibre. In the calcination step, different controlled temperature heating cycles were conducted to obtain fibres of different crystalline structures. Their biodurabilities were tested at pH 7.4 with lung airway epithelial lining fluid or serum ultrafiltrate (SUF) and at pH 4.5 with macrophage...

We present a particle-based method to simulate carbonate dissolution at the pore scale directly on the voxels of three-dimensional micro-CT images. The flow field is computed on the images by solving the incompressible Navier-Stokes equations. Rock-fluid interaction is modeled using a three-step approach: solute advection, diffusion, and reaction. Advection is simulated with a semianalytical po...

The effect of calcium on the dissolution and microbial reduction of a representative solid phase uranyl [U(VI)], sodium boltwoodite (NaUO(2)SiO(3)OH . 1.5H(2)O), was investigated to evaluate the rate-limiting step of microbial reduction of the solid phase U(VI). Microbial reduction experiments were performed in a culture of a dissimilatory metal-reducing bacterium (DMRB), Shewanella oneidensis ...

Introduction In vitro dissolution testing is a critical component in the assessment of quality of a pharmaceutical product and for the validation of the development and manufacturing process of a product (1). Dissolution testing is also used to assess the rate at which a drug is released from a dosage form,as it provides a manufacturer with a rational basis on which to predict in vivo behaviour...

The dissolution kinetics of the cotnn~on crystalline forms of cholesterol (anhydrate and monohydrate) were studied in free and conjugated chenodeoxycholate and ursodeoxycholate solutions by static disk, rotating disk, and powder dissolution techniques. 'The dissolution kinetics of both forms of cholesterol were found to be non-diffusion controlled, i.e., the detachment rate of cholesterol molec...

BACKGROUND Simvastatin is classified as a Biopharmaceutics Classification System (BCS) Class-II compound with a poor aqueous solubility and an acceptable permeability through biomembranes. The strategy of increasing the in vitro dissolution has the potential to enhance the oral bioavailability when using nanosized crystalline drugs. OBJECTIVE The aim of this article was to prepare simvastatin...