Neurleptic drugs, e.g., aripiprazole, targeting the dopamine D2S and D3 receptors (D2SR and D3R) in the central nervous system are widely used in the treatment of several psychotic and neurodegenerative diseases. Therefore, a new series of benzothiazole-based ligands (3-20) was synthesized by applying the bioisosteric approach derived from the selective D3Rs ligand BP-897 (1) and its structural...

From the Stroke Unit and Department of Neurology (A.C., A.S., R.S.), the Neuro­ interventional Unit and Department of Neuroradiology (L.V., E.B.), and the Bio­ statistics Service and Hematology De­ partment (M.N.), Niguarda Ca’ Granda Hospital, Milan; the Stroke Unit and Department of Neurology, Carlo Poma Hospital, Mantua (A.C.); and the Epide­ miology and Medical Statistics Section, Departmen...

Objective: It is known that point mutations, duplications and deletions occur in mitochondrial DNAs (mtDNA) of different tissues individuals. Among the observed, mt4977 mutation, which located at nucleotide positions 8470-8482 13447-13459 causes loss 4977 base pairs, most common. mtDNA deletion leads to 8 genes encoding subunits respiratory chain complexes. Consequently, could be expected inhib...

This paper sheds light on Maritime Education and Competence Development which has been investigated in various studies, both within and outside Europe. However, the topic is under-researched and stil l in need of attention, in order to ensure that competences are aligned with technological advancements and the needs that exist in a contemporary maritime industry. It is furthermore paramount tha...

a Masters program in Tropical Pathology, Universidade Federal do Amazonas (UFAM), Manaus, AM, Brazil b Residency in Infectious Diseases, Fundação de Medicina Tropical, Manaus, AM, Brazil c Medical School, Universidade Nilton Lins, Manaus, AM, Brazil d Graduate Program in Medical Sciences, Fundação Alfredo da Matta (FUAM), Manaus, AM, Brazil e Instituto Leônidas e Maria Deane, Fiocruz/AM, Manaus...

We read, with interest, the case report on extension of prayer-marks by Cangiano et al. and its association with worsening of the underlying chronic disease (1). We report a case where the occurrence of a similar skin lesion preceded an episode of acute coronary syndrome. A 45-year old man presented with sudden onset of severe retrosternal chest pain radiating to the found to be associated with...

abstract background: normal standard references of blood pressure (bp) for children and adolescents should be constructed according to anthropometric indices. therefore , we aimed to produce bp reference percentiles by body mass index (bmi). methods: data on demographic characteristics, anthropometric indices and bp values of 16246 3-18-year-old children and adolescents from 3 cross-sectional s...