Background: Alzheimer disease is the main cause of dementia in middle-aged and elderly people. Considering the improving effects of creatine supplementation on cognitive performance, this study aimed to determine the effects of creatine supplementation on learning, memory, and apoptosis in an experimental model of Alzheimer’s disease. Methods: Thirty-two male Wistar rats each weighing 250±50...

Objective(s): To evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion–detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (IR) injury. Materials and Methods: Eighteen female Wistar albino rats were used in control, IR, and IR+Edosteine (IR-E) groups, (n=6 in each). The IR-E group received the erdosteine for seven da...

Objective
 The study aimed to evaluate the antioxidant and
 antiapoptotic effects of Resveratrol (RES) against
 Methotrexate (MTX)-induced ovarian damage in
 female rats and were divided into 7 groups:
 Material Method
 Control; MTX (15mg/kg-1st day); (1st 3rd
 (1st, 3rd 5th day) +
 RES (20mg/kg); + RES; MTX
 RES. Since there was only
 one anima...

Abstract Traumatic brain injury (TBI) is a major cause of disabilities and deaths from acute injuries in the US worldwide. Neuroinflammation neuronal apoptosis are hallmarks TBI; however, mechanism clearance apoptotic debris by efferocytosis remains ill-defined. Our previous studies demonstrated that EphA4 receptor peripheral-derived macrophage (PDM) mediates pro-inflammatory response after inj...

objective(s): to evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion–detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (ir) injury. materials and methods: eighteen female wistar albino rats were used in control, ir, and ir+edosteine (ir-e) groups, (n=6 in each). the ir-e group received the erdosteine for seven da...