BACKGROUND The distinction of benign from malignant mesothelial proliferations in cytologic specimens can be problematic. In this study, the authors investigated the utility of immunohistochemical (IHC) markers in making this distinction. METHODS Archival paraffin-embedded cell blocks of pleural and peritoneal fluids from 52 patients with malignant mesothelioma (MM) and 64 patients with react...

BACKGROUND Routine Outcome Monitoring (ROM) is used as a means to enrich the process of treatment with feedback on patient outcomes, facilitating patient involvement and shared decision making. While traditional ROM measures focus on retrospective accounts of symptoms, novel mHealth technology makes it possible to collect real life, in-the-moment ambulatory data that allow for an ecologically v...

BACKGROUND A see on cardiovascular diseases and bladder cancer. The changes to the patterns of rosiglitazone and pioglitazone utilisation in Australia following the timing of these various health authority warnings such as the Australian Therapeutic Good Administration (TGA), European Medicines Agency (EMA) press releases or U.S. Food and Drug Administration (FDA) is unknown. This study investi...

BACKGROUND The European Medicines Agency (EMA) and national regulators share the responsibility to communicate to healthcare providers postmarketing safety events but little is known about the consistency of this process. We aimed to compare public availability of safety-related communications and drug withdrawals from the EMA and European Union member countries for novel medicines. METHODS A...

سابقه و هدف: هزینه مبادله که برخاسته از اقتصاد نهادگرا است، با مفهوم کارایی مرتبط است. یکی وظایف برنامه‌ریزان، افزایش فرایند برنامه‌ریزی به همین دلیل شناسایی عوامل مؤثر بر همچون هزینه‌های جست‌وجوی اطلاعات، مذاکره، ایجاد اعمال ساز­و­کارهای نظارتی حائز اهمیت زیرا این طریق است برنامه‌ریزان می‌توانند تکیه طراحی نهادی ساختارهای حکمرانی، را کاهش دهند. طرح تفصیلی در نظام ایران، برنامه‌ای بازیگران متعد...

Electromechanical actuators (EMAs) have shown a high efficiency in flight surface control with the development of more electric aircraft. In order to identify abnormalities and potential failures EMA, methodology for fault diagnosis is developed. A simulating model EMA first built perform different working states. Based on modeling corresponding faults are then simulated re-generate data. After...