We prove that for k ≥ 5 there does not exist a continuous map ∂CV (Fk) → PCurr(Fk) that is either Out(Fk)-equivariant or Out(Fk)-anti-equivariant. Here ∂CV (Fk) is the “length-function” boundary of Culler-Vogtmann’s Outer space CV (Fk), and PCurr(Fk) is the space of projectivized geodesic currents for Fk. We also prove that, if k ≥ 3, for the action of Out(Fk) on PCurr(Fk) and for the diagonal ...

In order to determine the ability of single-breath nitrogen closing volume (CV) to detect early airway obstruction, the CV was measured in patients with either minimal obstruction of spirometry or with increased residual volume (RV). A total of 39 subjects was included in this study. The mean CV was largest in patients who had reduced maximum mid-expiratory flow rates (MMF). There was no differ...

The cyanobacterial protein cyanovirin-N (CV-N) potently inactivates diverse strains of HIV-1 and other lentiviruses due to irreversible binding of CV-N to the viral envelope glycoprotein gp120. In this study, we show that recombinant CV-N effectively blocks HIV-1(Ba-L) infection of human ectocervical explants. Furthermore, we demonstrate the in vivo efficacy of CV-N gel in a vaginal challenge m...

OBJECTIVE To determine the influence of ischaemic cardiovascular (CV) risk on prescription of non-steroidal anti-inflammatory drugs (NSAIDs) by general practitioners (GPs) in patients with musculoskeletal complaints. DESIGN Cohort study. SETTING A healthcare database containing the electronic GP medical records of over one million patients throughout the Netherlands. PATIENTS A total of 4...

AIMS We investigated the potential influence of a moderate-to-high cardiovascular (CV) risk (CVR) (defined as a Systematic COronary Risk Evaluation model, or SCORE ≥ 4%), in the absence of an established CV disease, on the duration and cost of CV and non-CV sick leave (SL) resulting from common and occupational accidents or diseases. METHODS AND RESULTS We conducted a prospective cohort study...

Objective. To examine the association between the cardiovascular (CV) risk factors and triptans use among adults with migraine. Methods. A retrospective cross-sectional study design was used. Data were derived from 2009-2013 Medical Expenditure Panel Survey (MEPS). The study sample consisted of adults (age > 21 years) with migraine headache (N = 1,652). Multivariable logistic regression was use...