The IRS project has the overall aim of supporting the automated or semi-automated construction of semantically enhanced systems over the internet. IRS-I supported the creation of knowledge intensive systems structured according to the UPML framework and IRS-II integrated the UPML framework with web service technologies. In this paper we describe IRS-III. Within IRSIII we have now incorporated a...

The k-Interval Routing Scheme (k-IRS) is a compact routing scheme on general networks. It has been studied extensively and recently been implemented on the latest generation of the INMOS transputer router chips. In this paper we investigate the time complexity of devising a minimal space k-IRS and we prove that the problem of deciding whether there exists a 2-IRS for any network G is NP-complet...

Phosphatidylinositide (PI) 3-kinase binds to tyrosyl-phosphorylated insulin receptor substrate-1 (IRS-1) in insulin-treated adipocytes, and this step plays a central role in the regulated movement of the glucose transporter, GLUT4, from intracellular vesicles to the cell surface. PDGF, which also activates PI 3-kinase in adipocytes, has no significant effect on GLUT4 trafficking in these cells....

Nitric oxide (NO), which plays a role in the posttranslational modification of proteins, exhibits tumoricidal activity. However, the mechanism remains largely unclear. We investigated whether the regulation of insulin receptor substrate (IRS)-1 protein expression and insulin/insulin-like growth factor (IGF) signaling by NO is involved in the proliferation and invasion of pancreatic cancer cells...

ownload ic oxide (NO), which plays a role in the posttranslational modification of proteins, exhibits tumoricidal y. However, the mechanism remains largely unclear. We investigated whether the regulation of insulin resubstrate (IRS)-1 protein expression and insulin/insulin-like growth factor (IGF) signaling by NO is inin the proliferation and invasion of pancreatic cancer cells. NO donor inhibi...

OBJECTIVE To assess the relation of the metabolic insulin resistance syndrome (M-IRS) with coronary heart disease (CHD) in Pakistani patients. SUBJECTS 200 patients with angiographic disease (CHD(+)) matched with 200 patients with chest pain without occlusive disease (CHD(-)). DESIGN Prospective case-control study. SETTING Tertiary referral cardiology unit in Pakistan. RESULTS M-IRS was...

Insulin resistance is associated with cardiovascular disease. Impaired insulin receptor substrate (IRS)-mediated signal transduction is a major contributor to insulin resistance. Recently, IRS-1 phosphorylation at serine 307 by stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) has been highlighted as a molecular event that causes insulin resistance. We investigated IRS-1-mediat...

Channel estimation is a practical challenge for intelligent reflecting surface (IRS) aided wireless communication. As the number of IRS elements or IRS-aided users increases, channel training overhead becomes excessively high, which results in long delay and low throughput data transmission. To tackle this challenge, we propose paper new anchor-assisted approach, where two anchor nodes, namely ...

Insulin receptor substrates (IRSs) play central roles in insulin/insulin-like growth factor (IGF) signaling and mediate a variety of their bioactivities. IRSs are tyrosine-phosphorylated by activated insulin receptor/IGF-I receptor tyrosine kinase in response to insulin/IGF, and are recognized by signaling molecules possessing the SH2 domain such as phosphatidylinositol 3-kinase (PI3K), leading...