The function of insulin receptor substrate-1 (IRS-1) is regulated by both tyrosine and serine/threonine phosphorylation. Phosphorylation of some serine/threonine residues in IRS-1 dampens insulin signaling, whereas phosphorylation of other serine/threonine residues enhances insulin signaling. Phosphorylation of human IRS-1 at Ser(629) was increased by insulin in Chinese hamster ovary cells expr...

OBJECTIVE The objective of this systematic review is to summarize the literature to date on the rates of infusion reactions (IR) associated with chemotherapies and monoclonal antibody (mAb) drug therapies used for the treatment of metastatic colorectal cancer (mCRC) and the associated clinical and economic impact. METHODS This study searched Medline, Medline (R) In-Process, Embase and Cochran...

See online version for legend and references. systemic IR Apparently normal intrauterine growth and development, severe hyperglycemia and hyperke-tonemia, perinatal death as the result of diabetic ketoacidosis within 48–72 hours IRS-1 Retarded embryonal and postnatal growth, insulin resistance, normal fasting glycemia and normal or mild glucose intolerance, hyperinsulinemia IRS-2 Insulin resist...

The analysis and optimization of single intelligent reflecting surface (IRS)-assisted systems have been extensively studied, whereas little is known regarding multiple-IRS-assisted systems. This paper investigates the a double-IRS cooperatively assisted downlink system (D-IRS-C), where multi-antenna base station (BS) serves single-antenna user with help two multi-element IRSs, connected by an i...

The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) includes the development of insulin resistance and, at a later stage, impairment of b-cell response. In the past few years, different elements, including the proto-oncogene, Shc, and the insulin receptor substrate (IRS) proteins, have been found to have important roles in the insulin signaling network. Whithers et al. (1) have ...

در این مقاله، به‌منظور رفع برخی محدودیت‌های شناسایی ساختمان تصاویر چندطیفی، از دادة SAR به‌منزلة مکمل استفاده می‌شود. روش پیشنهادی، برای استفادة هم‌زمان اطلاعات مفید رادار و استراتژی مبتنی‌بر تلفیق تصاویر، با هدف ساختمان، مطرح همچنین، ازآن‌جاکه انتخاب ویژگی نقش بسزایی طبقه‌بندی عوارض دارد، اغلب روش‌های مرسوم رایج زمینه، مانند الگوریتم ژنتیک، نیازمند داده‌های آموزشی‌اند؛ اما دردسترس‌نبودن همیشگی...

IRS-III is the first WSMO compliant system for supporting the Semantic Web Services technologies and it is based on the IRS-II [3]. This paper presents how we integrated the OWL-S [5] service description ontology to IRS-III. We describe how the underlying model of IRS-III supports OWL-S.