BACKGROUND Limited published literature exists on the utility and standardization of anti-phospholipase A2 receptor (anti-PLA2R) immunohistochemistry (IHC) for the diagnosis of primary membranous nephropathy (MN). The study aimed to validate anti-PLA2R IHC for the diagnosis of primary MN and clinicopathological correlations in an Indian cohort. METHODS Subjects included patients with primary ...

1Center for Orphan Drug Research, University of Minnesota, Minneapolis, MN, USA, 2 Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA, 3 College of Science and Engineering, University of Minnesota, Minneapolis, MN, USA, 4 UMP MINCEP Epilepsy Care, Minneapolis, MN, USA, 5 Mayo Clinic, Rochester, MN, USA, 6 College of Veterinar...

We evaluated biochemical endpoints related to oxidative stress in brains of neonatal rats exposed to manganese (Mn). Oral Mn chloride (MnCl2) (0, 25, or 50 mg Mn chloride kg(-1) body weight per day) was given daily to neonatal rats throughout lactation (i.e. from postnatal day (PND) 1 to 21). As previously reported by [J. Appl. Toxicol. 20 (2000) 179], this treatment paradigm results in increas...

A rare-earth free red emitting β-Zn3B2O6:Mn(2+) phosphor was prepared by a solid-state reaction method. The crystal structure, photoluminescent and cathodoluminescent properties of β-Zn3B2O6:Mn(2+) were systematically investigated. The absorption and photoluminescence excitation spectra confirm that β-Zn3B2O6:Mn(2+) matches the UV LED chip. Under UV light and low-voltage electron beam excitatio...

Despite the fact that manganese (Mn) is known to be a neurotoxic element relevant to age-related disorders, the risk of oral exposure to Mn for age-related hearing loss remains unclear. In this study, we orally exposed wild-type young adult mice to Mn (Mn-exposed WT-mice) at 1.65 and 16.50 mg/L for 4 weeks. Mn-exposed WT-mice showed acceleration of age-related hearing loss. Mn-exposed WT-mice h...

Most intracellular Mn is found in mitochondria. We have used the shift in the manganese absorption edge in x-ray absorption near edge structure (XANES) spectroscopy to determine the oxidation state of Mn in brain, heart, and liver mitochondria, as well as in PC12 cells. We compared the XANES spectra of Mn in brain, heart, and liver mitochondria over a range of Mn concentrations with those of Mn...

Manganese (Mn) is an essential metal, but elevated cellular levels are toxic and may lead to the development of an irreversible parkinsonian-like syndrome that has no treatment. Mn-induced parkinsonism generally occurs as a result of exposure to elevated Mn levels in occupational or environmental settings. Additionally, patients with compromised liver function attributable to diseases, such as ...

The essential involvement of manganese in photosynthetic water oxidation was implicit in the observation by Pirson in 1937 that plants and algae deprived of Mn in their growth medium lost the ability to evolve O2. Addition of this essential element to the growth medium resulted in the restoration of water oxidation within 30 min. There is increased interest in the study of Mn in biological chem...

Many metabolic processes in plants are regulated by manganese (Mn) but limited information is available on the molecular mechanisms controlling cellular Mn homeostasis. In this study, a yeast assay was used to isolate and characterize two genes, MTP8.1 and MTP8.2, which encode membrane-bound proteins belonging to the cation diffusion facilitator (CDF) family in the cereal species barley (Hordeu...

Dedicated to Professor Heinrich Nöth on the occasion of his 85th birthday The new compound [Mn(dien)2][Mn(dien)SbS4]2 (dien = diethylenetriamine) was synthesized under solvothermal conditions. It crystallizes in the non-centrosymmetric monoclinic space group P21 with a = 7.5736(5), b = 19.1081(16), c = 13.1174(11) Å, β = 90.022(9)◦, V = 1898.3(3) Å3, and Z = 2. The crystal structure is composed...