Authors:Mika Naganawa1*, Rikki N Waterhouse2*, Nabeel Nabulsi, Shu-Fei Lin1, David Labaree1, Jim Ropchan1, Sanela Tarabar2, Nicholas DeMartinis2, Adam Ogden, Anindita Banerjee2, Yiyun Huang1, Richard E. Carson1 1PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 2Pfizer Worldwide Research and Development, Cambridge, MA *Co-first authors Correspond...

Cardioinhibitory and vasodepressor responses to different stressors on head-up tilt Arunashis Sau, Patricia Taraborrelli, Philip Moore, and Phang Boon Lim* Imperial College London, London, UK; Department of Cardiology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, Du Cane Road, London W12 0HS, UK; and Department of Cardiology, West Hertfordshire Hospitals NHS Trust, London, UK * ...

We present a kinematic study of the Herbig-Haro objects HH 202, 203 and 204 using Hα and [N II] Fabry-Perot velocity maps. For HH 202 we find new features that could belong to this HH object or that perhaps are associated with an outflow different from HH 202. Because of its high velocity (up to 100 km s) this outflow probably can be a HH flow not catalogued previously. Large internal motions a...

The mechanism of inactivation of porcine pancreatic elastase (PPE) by N-peptidyl-O-aroylhydroxylamine was studied by X-ray crystallography. The inactivator forms a stable complex with the enzyme by means of a covalent attachment to the active site Ser 203(195) O gamma. The nature of the complex is, however, different depending on the pH at which the inactivation reaction occurs. At pH 5, the co...

Glioblastoma stem cells (GBM-SCs) are believed to be a subpopulation within all glioblastoma (GBM) cells that are in large part responsible for tumor growth and the high grade of therapeutic resistance that is so characteristic of GBM. MicroRNAs (miR) have been implicated in regulating the expression of oncogenes and tumor suppressor genes in cancer stem cells, including GBM-SCs, and they are a...

Bottom-up (host plant quality) and top-down (natural enemies) forces both influence the fitness and population dynamics of herbivores. However, the impact of pollutants acting on these forces has not been examined, which prompted us to review the literature to test hypotheses regarding this area of research. A comprehensive literature search found 126 references which examined fitness component...

A presynthesized, square planar copper imidazole complex, [Cu(imidazole)4](NO3)2, was utilized as a precursor in the synthesis of a new series of zeolitic imidazolate frameworks, termed ZIF-202, -203, and -204. The structures of all three members were solved by single-crystal X-ray diffraction analysis, which revealed ZIF-203 and -204 having successfully integrated square planar units within th...

http://dx.doi.org/10.1016/j.jhydrol.2014.02.012 0022-1694/ 2014 Elsevier B.V. All rights reserved. ⇑ Corresponding author at: School of Forestry and Environmental Studies, Yale University, Kroon Hall, 195 Prospect Street, New Haven, CT 06511, USA. Tel.: +1 (203)432 6271; fax: +1 (203)432 5023. E-mail address: [email protected] (X. Lee). Wei Wang , Wei Xiao , Chang Cao , Zhiqiu Gao , Zhenghua H...

Glioblastoma multiforme (GBM) is the most malignant brain tumor with limited therapeutic options. Temozolomide (TMZ) is a novel cytotoxic agent used as first-line chemotherapy for GBM, however, some individual cells can't be isolated for surgical resection and show treatment-resistance, thus inducing poor prognosis. By using the HiSeq sequencing and bioinformatics methods, we identified lncRNAs...