نتایج جستجو برای: برنامه ca2

تعداد نتایج: 112265  

Journal: :The Journal of General Physiology 2001
Meredith A. Albrecht Stephen L. Colegrove Jarin Hongpaisan Natalia B. Pivovarova S. Brian Andrews David D. Friel

Many cells express ryanodine receptors (RyRs) whose activation is thought to amplify depolarization-evoked elevations in cytoplasmic Ca2+ concentration [Ca2+](i) through a process of Ca2+ -induced Ca2+ release (CICR). In neurons, it is usually assumed that CICR triggers net Ca2+ release from an ER Ca2+ store. However, since net ER Ca 2+ transport depends on the relative rates of Ca2+ uptake and...

Journal: :Circulation 1990
J K Gwathmey R J Hajjar

A novel approach was developed allowing the measurement of steady-state force and intracellular calcium concentration ([Ca2+]i) in tetanized human ventricular trabeculae carneae without pharmacological intervention. We compared and contrasted three methods of assessing calcium sensitivity of the myofilaments: 1) force-[Ca2+] relations in skinned fiber preparations, 2) peak twitch force-peak [Ca...

Journal: :Kidney international 2003
Ole Simonsen Daniele Venturoli Anders Wieslander Ola Carlsson Bengt Rippe

BACKGROUND In peritoneal dialysis, the rate of ultrafiltration has been predicted to be a major determinant of peritoneal calcium (Ca2+) removal. Hence, dialysis fluid glucose concentration should be an important factor governing the transperitoneal Ca2+ balance. The aim of this study was to test the effect of various dialysate glucose levels and selected dialysate Ca2+ levels on Ca2+ removal i...

Journal: :The Journal of pharmacology and experimental therapeutics 2005
Marcella Rocchetti Alessandra Besana Gaspare Mostacciuolo Rosella Micheletti Patrizia Ferrari Sandor Sarkozi Csaba Szegedi Istvan Jona Antonio Zaza

OBJECTIVE To gain some insight on the lesser arrhythmogenic properties of PST2744 [(E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride] compared with digoxin, we compared modulation of intracellular Ca2+ dynamics by the two agents. METHODS SERCA (sarcoplasmic reticulum Ca2+-ATPase) activity and Ca2+ leak rate were measured in sarcoplasmic reticulum (SR) vesicles from guinea pig ...

Journal: :The Journal of biological chemistry 1999
P Maechler E D Kennedy E Sebö A Valeva T Pozzan C B Wollheim

The precise regulation of the Ca2+ concentration in the endoplasmic reticulum ([Ca2+]er) is important for protein processing and signal transduction. In the pancreatic beta-cell, dysregulation of [Ca2+]er may cause impaired insulin secretion. The Ca2+-sensitive photoprotein aequorin mutated to lower its Ca2+ affinity was stably expressed in the endoplasmic reticulum (ER) of rat insulinoma INS-1...

Journal: :The Journal of General Physiology 2003
Don-On Daniel Mak Sean M.J. McBride Nataliya B. Petrenko J. Kevin Foskett

The inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R), a Ca2+-release channel localized to the endoplasmic reticulum, plays a critical role in generating complex cytoplasmic Ca2+ signals in many cell types. Three InsP3R isoforms are expressed in different subcellular locations, at variable relative levels with heteromultimer formation in different cell types. A proposed reason for this div...

Journal: :The Journal of biological chemistry 1979
M A Brostrom C O Brostrom D J Wolff

The Ca2+ content of glial tumor (C6) cells was reduced approximately 5-fold by repeated treatment with media containing ethylene glycol bis(beta-aminoethyl ether) N,N'-tetraacetic acid (EGTA) without loss of cellular viability. The ability of the cells to accumulate cAMP in response to beta-adrenergic agonists was reduced 60 to 70% following Ca2+ depletion. Ca2+ did not affect the apparent KACT...

Journal: :Journal of neurophysiology 1999
J Qian P Saggau

Presynaptic Ca2+ influx through voltage-dependent Ca2+ channels triggers neurotransmitter release. Action potential duration plays a determinant role in the dynamics of presynaptic Ca2+ influx. In this study, the presynaptic Ca2+ influx was optically measured with a low-affinity Ca2+ indicator (Furaptra). The effect of action potential duration on Ca2+ influx and transmitter release was investi...

2017
Mario Wakizaka Hiroaki Eshima Yoshinori Tanaka Hideki Shirakawa David C. Poole Yutaka Kano

In contrast to cardiomyocytes, store overload-induced calcium ion (Ca2+) release (SOICR) is not considered to constitute a primary Ca2+ releasing system from the sarcoplasmic reticulum (SR) in skeletal muscle myocytes. In the latter, voltage-induced Ca2+ release (VICR) is regarded as the dominant mechanism facilitating contractions. Any role of the SOICR in the regulation of cytoplasmic Ca2+ co...

Journal: :The Journal of experimental biology 2006
María A Martínez-Burgos María P Granados Antonio González Juan A Rosado María D Yago Ginés M Salido Emilio Martínez-Victoria Mariano Mañas José A Pariente

Reactive oxygen species and related oxidative damage have been implicated in the initiation of acute pancreatitis, a disease characterised in its earliest stages by disruption of intracellular Ca2+ homeostasis. The present study was carried out in order to establish the effect of the organic pro-oxidant, tert-butylhydroperoxide (tBHP), on the mobilisation of intracellular Ca2+ stores in isolate...

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