Three simple and sensitive extractive spectrophotometric methods have been described for the assay of terbinafine hydrochloride either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB) and bromocresol green (BCG) in acidic medium. The extrac...

Objective: A simple, direct and accurate spectrophotometric method has been developed for the determination of glimepiride (GLM) in pure and pharmaceutical formulations by complex formation with bromocresol green (BCG). Methods: The method involves the formation of a yellow ion-pair complex between bromocresol green reagent with glimepiride (C24H34N4O5S); after reacted it with Na2CO3 to give C2...

Sequential injection lab-at-valve (SI-LAV) micro-solvent extraction determination procedure for tetracycline hydrochloride in pharmaceutical analysis is proposed. It is based on the formation of a yellow colored ion associate of a protonated cation of tetracycline (TCLN) with anionic form of bromocresol green (BCG), in phthalate buffer pH 4, which could be extracted into dichloromethane. The or...

BACKGROUND There have been very few studies, with contradictory results, on the zinc status of children and adolescents with type-1 diabetes mellitus. The objective of this cross-sectional study was to determine zinc status based on the serum zinc concentration in type-1 diabetic children and adolescents and compare it with that of healthy controls. METHODS Thirty children and adolescents wit...

The objective of this study was to develop and validate a colorimetric assay to measure caprine serum albumin (CSA) concentrations in milk. The principle of the say was based on the binding of albumin to bromocresol green (BCG) dye at pH 4.0. The absorption of the dye-albumin complex was determined spectrophotometrically at 640 nm. A linear relationship existed between CSA concentrations (0.01 ...