MARK O. BEVENSEE,1 ESTHER BASHI,1 WOLF-RÜDIGER SCHLUE,2 GREGORY BOYARSKY,3 AND WALTER F. BORON1 1Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520; 2Institut für Neurobiologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany; and 3Department of Physiology and Biophysics, University of Texas Medical Branch, Galvesto...

This study was undertaken to elucidate the effect of diallyl disulfide from Allium sativum, an oil-soluble organosulfur compound found in garlic, in suppressing human non-small cell lung carcinoma H1299 cells. A potent increase in apoptotic cells has accompanied 1) a decrease in cell viability, 2) an increase of the fraction of G2/M-phase cells by up to 48.80 %, and 3) a transient increase of t...

Doolen, Suzanne, Diana N. Krause, and Sue P. Duckles. Estradiol modulates vascular response to melatonin in rat caudal artery. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1281–H1288, 1999.—The purpose of this study was to determine whether estrogen modulates the function of vascular melatonin receptors. We used the rat caudal artery and found that the contractile effects of melatonin were i...

A 19-year-old male college basketball player experienced onset of pain after playing 4 games in 2 days. Clinical examination revealed mild swelling over the mid-left tibia. There were no signs of infection. We obtained radiographs (Fig. 1). The radiological differential diagnosis at this stage included focal cortical abscess related to infection, stress fracture and osteoid osteoma. Computed to...

Foreman, R. D., R. W. Blair, H. R. Holmes, and J. A. Armour. Correlation of ventricular mechanosensory neurite activity with myocardial sensory field deformation. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R979–R989, 1999.—The mechanosensory activity generated by ventricular epicardial sensory neurites associated with afferent axons in thoracic sympathetic nerves was correl...

Callera, João Carlos, Leni G. H. Bonagamba, Anne Nosjean, Raul Laguzzi, and Benedito H. Machado. Activation of GABAA but not GABAB receptors in the NTS blocked bradycardia of chemoreflex in awake rats. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1902–H1910, 1999.—In the present study we analyzed effects of bilateral microinjections of muscimol (a GABAA agonist) and baclofen (a GABAB agonist...

Sharma, Ram V., Enqing Tan, Shengyun Fang, Milind V. Gurjar, and Ramesh C. Bhalla. NOS gene transfer inhibits expression of cell cycle regulatory molecules in vascular smooth muscle cells. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1450–H1459, 1999.—The mechanisms of nitric oxide (NO)-mediated inhibition of vascular smooth muscle (VSM) cell proliferation are still obscure. Cyclins A and E ...

O’Connor, Timothy P., Mandy M. Lam, and Jared Diamond. Magnitude of functional adaptation after intestinal resection. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1265–R1275, 1999.—Intestinal adaptation after resection has been much studied, but rarely examined in an integrative context. Hence we assessed the effects of resection and subsequent adaptation on the quantitative...

Rauch, Matthias, and Herbert A. Schmid. Functional evidence for subfornical organ-intrinsic conversion of angiotensin I to angiotensin II. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1630–R1638, 1999.—Using extracellular electrophysiological recording in an in vitro slice preparation, we investigated whether ANG I can be locally converted to the functionally active ANG II w...

Cui, Jian, Satoshi Iwase, Tadaaki Mano, and Hiroki Kitazawa. Responses of sympathetic outflow to skin during caloric stimulation in humans. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R738–R744, 1999.—We previously showed that caloric vestibular stimulation elicits increases in sympathetic outflow to muscle (MSNA) in humans. The present study was conducted to determine the e...