BACKGROUND Increased concentration of plasmatic homocysteine (tHcy) and decreased vitamin B 12 (B12) and folate (FOL) are associated with Alzheimer's (AD) and vascular (VaD) dementias, with type II diabetes mellitus (DM), and reported as risk factors of these diseases. METHODS The sample (n=122; males=60; mean age=73+/-7 years) comprised AD and VaD patients without DM, with a concomitant DM (...

The aim of this study was to develop methods for the in vitro propagation of Zantedeschia rehmannii. Zantedeschia rehmannii tuber fragments (1 cm2) containing eyes were soaked for 30 s in a solution containing 100 mg dm-3 L-ascorbic acid (AA) before transfer to culture vessels containing an MS medium supplemented with BAP (0 to 3 mg dm-3). Cultures were maintained in darkness. Soaking explants ...

Tibiotalocalcaneal arthrodesis (TTCA) has been used for the salvage of severe deformity involving the ankle and hindfoot. The purpose of this study was to evaluate the results of retrograde intramedullary nailing (IMN) for severe ankle/hindfoot pathology in a group of patients with diabetic neuropathy and compare them with a cohort of nondiabetic patients. Our working hypothesis was that patien...

INTRODUCTION AND OBJECTIVES Several guidelines on the treatment of cardiovascular risk factors base their recommendations on the assertion that diabetes mellitus (DM) is a coronary heart disease (CHD) or cardiovascular disease (CVD) risk equivalent. To date, no systematic review of studies substantiating this assertion has been carried out. METHODS A systematic search of the PubMed database u...

BACKGROUND Sleep-disordered breathing (SDB) is highly prevalent in patients with diabetes mellitus (DM) and heart failure (HF) and contributes to poor cardiovascular outcomes. Enlarged glycemic variability (GV) is a risk factor of cardiac events independently of average blood glucose level, but the influence of SDB on GV is uncertain. In this study, we examined whether the impact of SDB on GV i...

Diabetes mellitus (DM) is a disease defined by biochemical hyperglycemia. Currently it is classified into four major categories: type 1 DM (T1DM), type 2 DM (T2DM), gestational DM (GDM) and other DM. Within each category, the etiology is still heterogeneous. The pathogenesis of most DM is multi-factorial, including many genetic and environmental factors. T1DM, T2DM and GDM are polygenic. In the...

The mechanism of HLA-DM (DM) activity is still unclear. We have shown that DM-mediated peptide release from HLA-DR (DR) is dependent on the presence of exchange peptide. However, DM also promotes a small amount of peptide release in the absence of exchange peptide. Here we show that SDS-PAGE separates purified peptide/DR1 complexes (pDR1) into two conformers whose ratio is peptide K(d)-dependen...

Cosmic strings in the brane Universe have recently gained a great interest. I think the most interesting story is that future cosmological observations distinguish them from the conventional cosmic strings. If the strings are the higher-dimensional objects that can (at least initially) move along the compactified space, and finally settle down to (quasi-)degenerated vacua in the compactified sp...

In order to study the process of cooling in dark-matter (DM) halos and assess how well simple models can represent it, we run a set of radiative SPH hydrodynamical simulations of isolated halos, with gas sitting initially in hydrostatic equilibrium within Navarro-Frenk-White (NFW) potential wells. Simulations include radiative cooling and a scheme to convert high density cold gas particles into...

Strongly-Coupled Dark Energy plus Warm dark matter (SCDEW) cosmologies admit the stationary presence of ∼1% of coupled-DM and DE, since inflationary reheating. Coupled-DM fluctuations therefore grow up to non-linearity even in the early radiative expansion. Such early non-linear stages are modelized here through the evolution of a top-hat density enhancement, reaching an early virial balance wh...