Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae are endemic in New York City hospitals and have been associated with serious infections globally. A real-time polymerase chain reaction (RT-PCR) assay was developed to detect carbapenem resistance attributable to KPC from blood culture bottles positive for gram-negative bacilli. Culture confirmation of carbapenemase producti...

References 1 Yigit H, Queenan AM, Anderson GJ et al. Novel carbapenem-hydrolyzing b-lactamase KPC-1 from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 2001; 45: 1151–61. 2 Nordmann P, Naas T, Poirel L. Global spread of carbapenemaseproducing Enterobacteriaceae. Emerg Infect Dis 2011; 17: 1791–8. 3 Naas T, Cuzon G, Truong HV et al. Role of ISKpn7 and deletio...

Background: Nail biting (NB) is a common, but unresolved, problem in psychiatry, psychology, medicine and dentistry. It is the habit of biting one’s nails, is commonly observed in both children and young adults Materials & Methods: The study was a comparative cross‐ sectional microbiological study, conducted on the saliva samples of 40 chronic nail biting subjects in that 20 were males and 20 w...

The in vitro antibacterial activity of four beta-lactam antibiotics (cefatrizine [BL-S640], cefamandole, cefoxitin, and carbenicillin) and three aminoglycosides (amikacin, gentamicin, and tobramycin) was determined against 197 strains of cephalothin-resistant Enterobacteriaceae. Eighty strains were found to be gentamicin-sensitive, and 117 were found to be gentamicin-resistant. Carbenicillin wa...

The incidence of extended-spectrum beta-lactamases (ESBLs) was analyzed in Enterobacteriaceae population circulating in the Upper Silesian Child and Mother Health Center in Katowice (USC&MHC). Altogether 1164 clinical specimens, collected from children hospitalized in 8 different hospital units of USC&MHC were investigated. Five hundred and eighty-five clinical isolates of the family Enterobact...

Background. Enterobacteriaceae play an important role in the pathogenesis of hospital infections worldwide. The Tigecycline Evaluation Surveillance Trial (TEST) examines the susceptibility of pathogens isolated from multiple infectious processes from patients in geographically diverse populations. With the increase of antimicrobial resistance, continued surveillance and susceptibility testing o...

Increasing resistance to third generation cephalosporins has become a cause for concern especially among Enterobacteriaceae that cause nosocomial infections. The prevalence of extended spectrum beta-lactamases (ESBLs) among members of Enterobacteriaceae constitutes a serious threat to current beta-lactam therapy leading to treatment failure and consequent escalation of costs. A detailed study w...

During the last decade, Gram-negative clinical isolates, including Enterobacteriaceae, Pseudomonas spp. and Acinetobacter spp. with decreased susceptibility to carbapenems, have been increasingly reported in Europe. Carbapenem resistance in Enterobacteriaceae may be related either to the association of a decrease in bacterial outer-membrane permeability with overexpression of b-lactamases posse...

This study compared the in vitro activities of ertapenem, ceftriaxone, co-amoxiclav, ciprofloxacin and piperacillin-tazobactam against 314 aerobic bacteria and of ertapenem, piperacillin-tazobactam, cefoxitin, ceftriaxone, chloramphenicol, ticarcillin-clavulanate, ampicillin-sulbactam, clindamycin and metronidazole against 500 anaerobic bacteria from 212 patients with acute pelvic infection. An...