To study the efficiency of Polymerase Chain Reaction for the diagnosis of clinically suspected tuberculous meningitis, a rapid molecular technique was established. The conventional bacteriological methods rarely detect Mycobacterium tuberculosis in CSF and are of limited use in diagnosis of tuberculous meningitis (TBM). This double blind study was, therefore, directed to the molecular analysis ...

We present a novel persistent homological sparse network analysis framework for characterizing white matter abnormalities in tensor-based morphometry (TBM) in magnetic resonance imaging (MRI). Traditionally TBM is used in quantifying tissue volume change in each voxel in a massive univariate fashion. However, this obvious approach cannot be used in testing, for instance, if the change in one vo...

CD34+ human marrow cells not expressing T cell-, B cell-, and myeloid cell-associated antigens (TBM-) were cloned by two-color cell sorting into culture wells containing irradiated marrow stromal cells. After 4 wk of culture, 3.7 +/- 2.1% of these cells generated colony-forming cells (CFC), with each of these cells generating 6.3 +/- 5.3 CFC. This was not due to the 0.5 +/- 0.5% CFC present in ...

greater levels of complexity in tunnelling with tunnel boring machine (tbm) allow higher chances of failures that may increase the potential hazardous risks. this paper presents the results of a study on tbm reliability using risk analysis. machinery failure mode and effect analysis was applied to analyze the risks of a tbm using qs9000 and sae.j1739 recommendations. for this purpose, 48 failur...

Computed tomography (CT) is gaining widespread usage as an aid to tuberculous meningitis (TBM) diagnosis for the examination of a number of visual indicators of the disease. We present an algorithm that uses modified fuzzy c-means clustering to segment CT images of the brain into various tissue types. The end result is that hyperdense areas of the brain are delineated, which aids the radiologis...

There are no data about the comparative accuracy of commercially available nucleic acid amplification tests (GeneXpert MTB/RIF and Roche Amplicor) for the diagnosis of tuberculous meningitis (TBM). A total of 148 patients with suspected TBM were evaluated, and cultures served as the reference standard. The sensitivities and specificities (95% confidence interval [CI]) for the Amplicor and Xpert...

To address the issue of whether tri-bimaximal mixing (TBM) is a softly-broken hidden or an accidental symmetry, we adopt a model-independent analysis in which we perturb a neutrino mass matrix leading to TBM in the most general way but leave the three texture zeros of the diagonal charged lepton mass matrix unperturbed. We compare predictions for the perturbed neutrino TBM parameters with those...

In the April 2006 issue of the Journal of Clinical Microbiology, Shah et al. reported the simultaneous presence of Mycobacterium tuberculosis and Mycobacterium bovis in 22 human cerebrospinal fluid specimens (5). The method used to reveal the alleged coinfection was a novel nested PCR (N-PCR) described by Mishra et al. (3). In that original study, N-PCR correlated as poorly with culture (85/189...

BACKGROUND Dexamethasone has been shown to reduce mortality in patients with tuberculous meningitis but the long-term outcome of the disease is unknown. METHODS Vietnamese adults and adolescents with tuberculous meningitis recruited to a randomised, double-blind, placebo-controlled trial of adjunctive dexamethasone were followed-up at five years, to determine the effect of dexamethasone on lo...