OBJECTIVES To investigate whether nigrostriatal dopaminergic hypofunction is related to the extrapyramidal symptoms in patients with juvenile neuronal ceroid lipofuscinosis (JNCL). METHODS Nine patients with JNCL and seven healthy controls were studied using [18F]fluorodopa PET. RESULTS In the patients with JNCL [18F]fluorodopa uptake (K[i][occ]) in the putamen was 60% of the control mean a...

Theories of organizational culture and climate (OCC) applied to child welfare systems hypothesize that strategic dimensions of organizational culture influence organizational climate and that OCC explains system variance in youth outcomes. This study provides the first structural test of the direct and indirect effects of culture and climate on youth outcomes in a national sample of child welfa...

Petri Place/Transition (PT) nets are one of the most widely used models of concurrency. However, they still lack, in our view, a satisfactory semantics: on the one hand the \token game" is too intensional, even in its more abstract interpretations in term of nonsequential processes and monoidal categories; on the other hand, Winskel's basic unfolding construction, which provides a coreeection b...

This study investigated the participation of MAPK in the resumption of meiosis [germinal vesicle breakdown (GVB)] in oocytes and cumulus expansion using oocyte-cumulus cell complexes (OCC) from Mos-null mice (Mos(tm1Ev)/Mos(tm1Ev), hereafter Mos(-/-)). MAPK activity was not detected in Mos(-/-) oocytes whether they matured in vivo or in vitro, with or without gonadotropin stimulation. Therefore...

It has been previously demonstrated that Gi/o proteins are involved in ischemic preconditioning (IPC) in rabbits and dogs; however, there has been controversy as to the role of Gi/o proteins in IPC in in vivo rat infarct models. Therefore, the role of G proteins in the cardioprotective effect of IPC in a rat infarct model was reevaluated. Cardioprotection as indicated by infarct size (IS) as a ...

Rapid growth of technical developments has created huge challenges for microphone forensics a subcategory of audio forensic science, because of the availability of numerous digital recording devices and massive amount of recording data. Demand for fast and efficient methods to assure integrity and authenticity of information is becoming more and more important in criminal investigation nowadays...

We introduce the first index that can be built in o(n) time for a text of length n, and also queried in o(m) time for a pattern of length m. On a constant-size alphabet, for example, our index uses O(n log n) bits, is built in O(n/ log n) deterministic time, and finds the occ pattern occurrences in time O(m/ logn + √ logn log logn + occ), where ε > 0 is an arbitrarily small constant. As a compa...