BACKGROUND Genetic studies have shown lipoprotein(a) (Lp[a]) to be an important causal risk factor for coronary disease. Apolipoprotein(a) isoform size is the chief determinant of Lp(a) levels, but its impact on the benefits of therapies that lower Lp(a) remains unclear. METHODS HPS2-THRIVE (Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events) is a randomized ...

High density lipoproteins (HDL) consist of a mixture of chemically and functionally distinct families of particles defined by their characteristic apolipoprotein (Apo) composition. The two major lipoprotein families are lipoprotein A-I (LP-A-I) and lipoprotein A-I:A-II (LP-A-I:A-II). This study describes the isolation of a third minor HDL family of particles referred to as lipoprotein A-II (LP-...

Lipoprotein(a) (Lp[a]) is an atherogenic lipoprotein which is similar in structure to low density lipoproteins (LDL) but contains an additional protein called apolipoprotein(a) (apo[a]). Apo(a) is highly polymorphic in size, and there is a strong inverse association between the size of the apo(a) isoform and the plasma concentration of Lp(a). We directly compared the in vivo catabolism of Lp(a)...

The proper development and maturation of neuronal circuits require precise migration of component neurons from their birthplace (germinal zone) to their final positions. Little is known about the effects of aberrant neuronal position on the functioning of organized neuronal groups, especially in mammals. Here, we investigated the formation and properties of brainstem respiratory neurons in loop...

Background: Participation in physically active games is one way to increase energy expendture in children. However, it is unknown whether adult leader participation (LP) in games can impact children’s physical activity (PA) levels. The purpose of this study was to examine the influence of LP compared to no LP on PA levels among children participating in organized active games. Methods: Children...

RATIONALE Lipoprotein(a) [Lp(a)] is a low-density lipoprotein-like lipoprotein and important cardiovascular risk factor whose cognate receptor and intracellular fate remains unknown. OBJECTIVE Our study aimed to determine the intracellular trafficking pathway for Lp(a) and the receptor responsible for its uptake in liver cells. METHODS AND RESULTS Human hepatoma cells were treated with Lp(a...

We investigated age- and sex-related differences in the structure and composition of two species of lipoproteins that contain apoprotein (apo) A-I (A-I Lp): lipoproteins containing apo A-I and apo A-II (Lp A-I/A-II), and lipoprotein containing apo A-I but no apo A-II (Lp A-I), which were isolated by immunoaffinity chromatography. Sixty normolipidemic volunteers were assigned to one of three gro...

in this paper we initiate the study of real group algebras and investigate some of its aspects.let l1 (g) be a group algebra of a locally compact group g,τ :g →g be a group homeomorphismsuch that τ 2 =τοτ = 1, the identity map, and lp (g,τ ) = { f ∈ lp (g) : fοτ = f } ( p ≥ 1) . in thispaper, among other results, we clarify the structure of lp (g,τ ) and characterize amenability ofl1 (g,τ ) and...

lichen planus (lp) is a chronic mucocutaneous disease widely recognized in adults, but uncommon in children. the purpose of this paper is to report two cases of lp in children. the diagnosis was made based on clinical and histopathological findings. the treatment consisted of antifungal and multivitamin therapy. regression of lesions was observed. the patients are still under follow up. althoug...

We present an Itô formula for the Lp-norm of jump processes having stochastic differentials in Lp-spaces. The main results extend well-known theorems Krylov to case with jumps, which can be used prove existence and uniqueness Lp-spaces SPDEs driven by Lévy processes.