Let X denote a compact Riemann surface of genus g. Let K denote the canonical line bundle on X and denote by K n the n-fold tensor power of K. Put dn=dimcH~ Kn)=(2n-1 ) (g -1 )+b ln . At each point P~X, there is a sequence of d, integers 1 = 71 (P) < 72(P) < " " < 7a~(P) < 2 n ( g 1) + 1, called the sequence of n-gaps at P. An integer 7 is an n-gap at P if and only if there exists O~H~ K ~) wit...

BACKGROUND The diffusion of antibiotics through the outer membrane is primarily affected by the porin super family, changes contribute to antibiotic resistance. Recently we demonstrated that the CpxAR two-component signaling system alters the expression of an uncharacterized porin OmpC(KP), to mediate antimicrobial resistance in K. pneumoniae. PRINCIPAL FINDINGS In this study, functional char...

The deacetoxycephalosporin C synthase (DAOCS) from Streptomyces clavuligerus was engineered with the aim of enhancing the conversion of penicillin G into phenylacetyl-7-aminodeacetoxycephalosporanic acid, a precursor of 7-aminodeacetoxycephalosporanic acid, for industrial application. A single round of random mutagenesis followed by the screening of 5,500 clones identified three mutants, G79E, ...

85Sr as radioindicator has been applied to strontium separation selectivity study using cisdicyclohexano-18-crown-6 (DCH18C6) extraction agent and picric acid counter ion with the aim contribute development of a rapid method extraction. The same used for fractionation in chosen soils by application Tessier- BCR sequential procedures. Experimental results have shown, that mentioned system is app...

In this paper, we introduce the concepts of n-fold obstinate pseudo-hoop and n-fold obstinate filter in pseudo-hoops. Then we investigated these notions and proved some properties of them. Also, we discussed the relationship between n-fold obstinate pseudo-hoop and n-fold obstinate filter and other types of n-fold pseudo-hoops and n-fold filters such as n-fold (positive) implicative filter and ...

We construct the full linearisation functor which takes a graded bundle of degree k (a particular kind of graded manifold) and produces a k-fold vector bundle. We fully characterise the image of the full linearisation functor and show that we obtain a subcategory of k-fold vector bundles consisting of symmetric k-fold vector bundles equipped with a family of morphisms indexed by the symmetric g...

UNLABELLED K-Fold is a tool for the automatic prediction of the protein folding kinetic order and rate. The tool is based on a support vector machine (SVM) that was trained on a data set of 63 proteins, whose 3D structure and folding mechanism are known from experiments already described in the literature. The method predicts whether a protein of known atomic structure folds according to a two-...

Loop 52-72 of porcine fructose-1,6-bisphosphatase may play a central role in the mechanism of catalysis and allosteric inhibition by AMP. The loop pivots between different conformational states about a hinge located at residues 50 and 51. The insertion of proline separately at positions 50 and 51 reduces k(cat) by up to 3-fold, with no effect on the K(m) for fructose 1,6-bisphosphate. The K(a) ...

Although K-ras is frequently mutated in lung adenocarcinomas, the normal function of K-ras p21 in lung is not known. In two mouse (E10 and C10) and one human (HPL1D) immortalized lung cell lines from peripheral epithelium, we have measured total K-ras p21 and active K-ras p21-GTP during cell proliferation and at growth arrest caused by confluence. In all three cell types, total K-ras p21 increa...

Glutamate dehydrogenase (NAD) activity was measured in liver and diaphragm mitochondria from 48 h fasted rats. Kinetic studies were performed with diaphragm enzyme and the effects of L-leu, ADP and L-ala on the K(1)m and V(1)max for NH(4)+, and α-ketoglutarate were evaluated. L-leucine increases by 2-8 fold the V(1)max for all three substrates with no significant changes in the K(1)m. ADP incre...