The pathogenesis of the spontaneous glomerulonephritis of NZB and (NZB x NZW) F(1) hybrid mice is related at least in part to the formation of natural antibody against antigens of the G (Gross) system, and apparently to the deposition in the glomeruli of immune complexes of G natural antibody with G soluble antigen (GSA), type-specific antigen specified by wild-type Gross leukemia virus. G natu...

In recent years, various heuristic optimization methods have been developed. Many of these methods are inspired by swarm behaviors in nature. In this paper, a new optimization algorithm based on the law of gravity and mass interactions is introduced. In the proposed algorithm, the searcher agents are a collection of masses which interact with each other based on the Newtonian gravity and the la...

Suramin acts as a G protein inhibitor because it inhibits the rate-limiting step in activation of the Ga subunit, i.e., the exchange of GDP for GTP. Here, we have searched for analogues that are selective for Gsa. Two compounds have been identified: NF449 (4,4*,4(,4*(-[carbonyl-bis[imino-5,1,3benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-1,3disulfonate) and NF503 (4,4*-[carbonylbis[imino-...

By inhibiting techniques using indirect immunofluorescence tests and indirect immunoelectron microscopy, the G(Gross) soluble antigens (GSA) in the body fluids of AKR and C58 mice, which have a high incidence of spontaneous leukemia, were classified according to the known specificity of G antigens in the murine Gross leukemia system. GSA existing in the plasma of nonleukemic and leukemic AKR mi...

Many mathematical and computational models used in engineering produce multivariate output that shows some degree of correlation. However, conventional approaches to Global Sensitivity Analysis (GSA) assume that the output variable is scalar. These approaches are applied on each output variable leading to a large number of sensitivity indices that shows a high degree of redundancy making the in...

This paper proposes a novel and efficient hybrid algorithm based on combining particle swarm optimization (PSO) and gravitational search algorithm (GSA) techniques, called PSO-GSA. The core of this algorithm is to combine the ability of social thinking in PSO with the local search capability of GSA. Many practical constraints of generators, such as power loss, ramp rate limits, prohibited opera...

This paper will explore the use of autoencoders for semantic hashing in the context of Information Retrieval. This paper will summarize how to efficiently train an autoencoder in order to create meaningful and low-dimensional encodings of data. This paper will demonstrate how computing and storing the closest encodings to an input query can help speed up search time and improve the quality of o...

The public p53 data set contains expression profile with 33 samples carrying mutated p53 and 17 samples classified as normal [4]. The aim is to find which processes are affected due to dysfunction of p53. We applied CePa and standard GSA method on NCI-Nature catalogue from PID database. For CePa, we used the absolute t-value as node-level statistic and mean as the pathway level transformation. ...

Tc-99m DTPA galactosyl human serum albumin (Tc-99m GSA) hepatic scintigraphy was performed in two patients with patent ductus venosus before and after operation. To evaluate the portosystemic shunt flow, per-rectal portal scintigraphy with I-123 N-isopropyl-p-iodoamphetamine (IMP) was undergone in the same period. The portosystemic shunt indices (PSS index) were decreased from 67.9% to 7.3% in ...