نتایج جستجو برای: افزایشی ace

تعداد نتایج: 21993  

2017
Rita Schüler Martin A. Osterhoff Turid Frahnow Anne‐Cathrin Seltmann Andreas Busjahn Stefan Kabisch Li Xu Alexander S. Mosig Joachim Spranger Matthias Möhlig Silke Hornemann Michael Kruse Andreas F. H. Pfeiffer

BACKGROUND Angiotensin-converting enzyme (ACE) plays a major role in blood pressure regulation and cardiovascular homeostasis. Contrary to the assumption that ACE levels are stable, circulating ACE has been shown to be altered in obesity and weight loss. We sought to examine effects of a high-saturated-fat (HF) diet on ACE within the NUtriGenomic Analysis in Twins (NUGAT) study. METHODS AND R...

Journal: :American journal of physiology. Heart and circulatory physiology 2004
María Paz Ocaranza Guillermo Díaz-Araya Juan E Carreño David Muñoz Juan Pablo Riveros Jorge E Jalil Sergio Lavandero

In humans, the effect of angiotensin-converting enzyme (ACE) gene polymorphisms in cardiovascular disease is still controversial. In the rat, a microsatellite marker in the ACE gene allows differentiation of the ACE gene polymorphism among strains with different ACE levels. We tested the hypothesis that this ACE gene polymorphism determines the extent of cardiac fibrosis induced by isoprotereno...

Journal: :Journal of the renin-angiotensin-aldosterone system : JRAAS 2011
Liza Ljungberg Urban Alehagen Toste Länne Hanna Björck Rachel De Basso Ulf Dahlström Karin Persson

INTRODUCTION A polymorphism in the angiotensin-converting enzyme gene (ACE I/D polymorphism) has been associated with increased risk for cardiovascular disease (CVD). This polymorphism affects the level of circulating ACE, but there is great individual variation, even between those with the same genotype. Few previous studies have investigated the link between circulating ACE and cardiovascular...

2017
Michael Bruneau Theodore J Angelopoulos Paul Gordon Niall Moyna Paul Visich Robert Zoeller Rick Seip Stephen Bilbie Paul Thompson Joseph Devaney Heather Gordish-Dressman Eric Hoffman Linda S Pescatello

BACKGROUND The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism (rs4340) (ACE DIP) accounts for half of the variability in plasma ACE concentrations. ACE has been widely studied for its influence on sports performance; however, research on its influence in physical activity is limited and inconsistent. We examined the influence of the ACE DIP on physical activity among ...

Journal: :Chest 2002
Henry Völzke Julia Engel Volker Kleine Christian Schwahn Johannes B Dahm Lothar Eckel Rainer Rettig

STUDY OBJECTIVES This study was designed to evaluate whether the insertion (I)/deletion (D) polymorphism of the angiotensin I-converting enzyme (ACE) gene is associated with mortality and cardiac morbidity after coronary artery bypass graft surgery (CABG). METHODS AND RESULTS The ACE I/D genotype was determined in 249 consecutive patients who underwent CABG. Follow-up information (after 2 yea...

Journal: :Genetics 1981
J G Culotti G Von Ehrenstein M R Culotti R L Russell

In JOHNSON et al. (1981), the Caenorhabditis elegans mutant strain PR1000, homozygous for the ace-1 mutation p1000, is shown to be deficient in the class A subset of acetylcholinesterases, which comprises approximately one-half of the total C. elegans acetylcholinesterase activity. Beginning with this strain, we have isolated 487 new behavioral and morphological mutant strains. Two of these, in...

Journal: :Hypertension 2005
Zhenlong Chen Fulong Tan Ervin G Erdös Peter A Deddish

We measured the cleavage of angiotensin I (Ang I) metabolites by angiotensin I-converting enzyme (ACE) in cultured cells and examined how they augment actions of bradykinin B2 receptor agonists. Monolayers of Chinese hamster ovary cells transfected to stably express human ACE and bradykinin B2 receptors coupled to green fluorescent protein (B2GFP) or to express only coupled B2GFP receptors. We ...

Journal: :The Journal of biological chemistry 1998
E Villard A Alonso M Agrapart M Challah F Soubrier

Angiotensin I-converting enzyme (ACE) has been implicated in various cardiovascular diseases; however, little is known about the ACE gene regulation in endothelial cells. We have investigated the effect of the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) on ACE activity and gene expression in human umbilical vein endothelial cells (HUVEC). Our results showed a 3- and 5-fold ...

Journal: :Heart 2001
R J MacFadyen C G Fraser A D Struthers

For an individual congestive heart failure (CHF) patient to gain maximum benefit from their angiotensin converting enzyme (ACE) inhibitor treatment, it is important for him or her to adhere fully with treatment. Many studies suggest that non-adherence with drug treatment is common in CHF patients and that this leads to increased hospitalisation and even death. Since ACE inhibitors reduce mortal...

ژورنال: :مجله علوم پزشکی رازی 0
محسن فیروزرای m. firoozrai, biochemistry department, cellular and molecular research center, crossing of hemmat and chamran expressways,گروه بیوشیمی، مرکز تحقیقات سلولی و مولکولی، تقاطع شهید چمران و همت علی محمد شریفی a.m. sharifi, cellular and molecular research center,مرکز تحقیقات سلولی و مولکولی محمد نجفی m. najafi, لادن حسینی گوهری l. hosseini gohari, faculty of para medical sciences, cellular and molecular research center,دانشکده پیراپزشکی، مرکز تحقیقات سلولی و مولکولی،

زمینه و هدف: در حال حاضر مهم ترین علت مرگ و میر در کشورهای در حال توسعه، بیماری های قلبی و عروقی (cad=coronary artery disease) است. در اتیولوژی این بیماری، فاکتورهای مختلفی شرکت دارند. در این مطالعه، برخی از فاکتورهای مهم مورد ارزیابی قرار گرفتند. روش بررسی: در این مطالعه مقطعی، 94 فرد سالم و 106 فرد بیمار مبتلا به تنگی عروق بیش از 50% که جهت آنژیوگرافی به بیمارستان شهید رجایی مراجعه کرده بودند...

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