Two optically active (100% enantiomeric excess) isomers of ofloxacin [(+/-)-ofloxacin; DL-8280; (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7 H-pyrido[1,2,3-de] [1,4] benzoxazine-6-carboxylic acid] were prepared by use of their optically resolved synthetic intermediates. One of the isomers, (-)-ofloxacin, was 8 to 128 times more potent in inhibiting the multiplication ...

CIGB-300, formerly known as P15-tat, is a proapoptotic peptide with established antiproliferative activity in vitro and antitumoral activity in vivo. This hypothesis-driven peptide was initially selected for its ability to impair the in vitro CK2-mediated phosphorylation in one of its substrates through direct binding to the conserved acidic phosphoaceptor domain. However, the actual in vivo ta...

 Though conception rates within 2 weeks of Eazi-BrEEd CIDR removal were lower for treated cows (27.7% vs 36.2% for controls, P < 0.083), overall pregnancy rates did not differ between treatment groups (P = 0.32). [Conception can be reduced by: 1) an older, unknown-aged egg being ovulated after an extended progesterone period; 2) vaginitis, so cleanliness and proper insertion technique are impo...

The myocardium of the embryonic chick heart, before it has been innervated, responds to concentrations of epinephrine as dilute as 1 part in 20,000,000 by an abrupt acceleration in its inherent rate of pulsation. The more slowly the heart beats initially, the more marked is the accelerating effect of epinephrine. Usually the initial acceleration is followed by a period during which the heart sl...

BACKGROUND Health care providers' lack of education on spiritual care is a significant barrier to the integration of spiritual care into health care services. OBJECTIVE The study objective was to describe the training program, Clinical Pastoral Education for Healthcare Providers (CPE-HP) and evaluate its impact on providers' spiritual care skills. METHODS Fifty CPE-HP participants completed...

Abstract. Unique spectroscopic possibilities open up if a laser beam interacts with relativistic lithium-like ions stored in the heavy ion ring accelerator SIS300 at the future Facility for Antiproton and Ion Research FAIR in Darmstadt, Germany. At a relativistic factor γ = 36 the 2P1/2 level can be excited from the 2S1/2 ground state for any element with frequency doubled dye-lasers in colline...